代谢综合征对室性期前收缩患者期前收缩负荷及血尿酸的影响

Effect of metabolic syndrome on premature ventricular contraction burden and serum uric acid level

目的探讨代谢综合征(MS)对室性期前收缩(PVC)患者期前收缩负荷、血尿酸及心功能参数的影响。方法回顾性分析151例PVC患者的临床特点,根据是否合并MS分2组,PVC合并MS为合并组60例,PVC未合并MS为未合并组91例,分析2组PVC负荷和心功能参数等。结果与未合并组比较,合并组PVC频次、PVC负荷、血尿酸水平明显升高[(15808.5±10202.9)次vs(12151.8±7215.9)次、(15.7±9.5)%vs(12.2±6.9)%、(339.27±101.95)μmol/Lvs(307.85±83.56)μmol/L,P<0.05];合并组左心室质量指数明显升高,LVEF明显降低(P<0.05)。结论MS可能促进血尿酸升高及PVC的发展,引起心脏结构及功能改变,应早期给予干预。

Objective To study the effect of MS on premature ventricular contraction（PVC） burden and serum UA level in PVC patients.Methods The clinical data of 151 PVC patients were retrospectively analyzed in this study.The patients were divided into PVC＋MS group（group I,n = 60） and PVC group（group Ⅱ n=91）.After they underwent 24 h dynamic electrocardiogrphy,Doppler echocardiography,their PVC burden,laboratory findings and cardiac function were comparatively analyzed.Results The PVC frequency,PVC burden,serum UA levels were significantly higher in group Ⅰ than in group Ⅱ（15808.5 ＋ 10202.9 times vs 12151.8 ＋ 7215.9 times,15.7%＋ 9.5%vs 12.2%＋ 6.9%,339.27 ＋ 101.95 μmol/L vs 307.85 ＋ 83.56 μmol/L,P〈0.05）.The LVMI was significantly greater,and the LVEF was significantly lower in group I than in groupⅡ（P〈0.05）.Conclusion MS can increase serum UA level,promote progress of PVC,induce changes of cardiac structure and function,and should thus be intervened as early as possible.