静脉滴注夫西地酸钠外渗致小儿手伸指肌腱粘连

Finger tendon adhesion in a child due to exosmosis of sodium fusidate when Ⅳ infusion

1例2岁女性患儿因支气管肺炎给予夫西地酸钠125 mg入0.9%氯化钠注射液100 ml静脉滴注，1次/d。用药第5天输入药液80 ml时发现患儿左手背进针处药液外渗，左手背肿胀面积约3.0 cm ×3.5 cm。立即停止静脉滴注，局部给予硫酸镁湿敷和多磺酸粘多糖乳膏外涂。9 d后患儿左手背肿胀明显消退，局部皮肤无明显坏死症状。出现外渗后36 d家长发现患儿左手第3、4、5伸指肌腱粘连，不能抓握。行左手掌指关节第3、4、5指伸肌腱粘连松解术。术后功能锻炼3个月。术后6个月随访，患儿手功能恢复良好。

A 2-year-old girl with bronchopneumonia received an IV infusion of sodium fusidate 125 mg in 0. 9% sodium chloride 100 ml once daily. On day 5,extravasation of liquid medicine was found on left opisthenar when 80 ml liquid medicine was infused. The swelling area on the back of left hand was about 3. 0 cm × 3. 5 cm. The IV infusion was stopped immediately and magnesium sulphate hydropathic compress and mucopolysaccharide polysulfate cream were given. The swelling on back of left hand was subsided evidently nine days later. There was no symptom of necrosis in local skin. The parents found that tendon adhesion in girl′s third,fourth and fifth fingers 36 days after extravasation. The girl could not do the action of taking object by hand. The girl received the lysis of adhesions of tendon on the third,fourth and fifth fingers. The girl performed physical exercise for three months after operation. The follow-up result showed that the girl′s hand function were well recovered on 6 months after operation.