阿普唑仑渐进式加量治疗慢性耳鸣的疗效与安全性观察

Observation on the Efficacy and Safety of Alprazolam by Progressive Dose Increasing in the Treatment of Chronic Tinnitus

目的:观察阿普唑仑渐进式加量治疗慢性耳鸣的临床疗效与安全性。方法:50例慢性耳鸣患者于第1、2周给予阿普唑仑片0.4 mg,口服,每晚睡前服用1次;第3、4周给予阿普唑仑片0.4 mg,口服,每日早晚各1次;第5、6周给予阿普唑仑片0.4 mg,口服,每日3次。耳鸣无效者,逐渐停药,停药以0.4 mg,每日2次,连用3 d;后改为0.4 mg,每日1次,连用3 d,后停药。有效者继续维持用药12周,随后逐渐停药,停药后随访3个月。观察所有患者的临床疗效,治疗前后耳鸣致残量表(THI)评分、视觉模拟量表(VAS)评分、耳鸣响度(TI)及不良反应发生情况。结果:总有效率为66.67%;所有患者治疗后THI评分、VAS评分、TI均显著低于治疗前,差异均有统计学意义(P<0.05);治疗期间均未见明显不良反应发生。结论:阿普唑仑渐进式加量治疗慢性耳鸣疗效显著,且安全性较好。

OBJECTIVE：To observe the efficacy and safety of alprazolam by progressive dose increasing in the treatment of chronic tinnitus. METHODS：Totally 50 patients with chronic tinnitus were included. They were orally treated with Alprazolam tablet 0.4 mg in the first 1 and 2 week（s）,once every night at bedtime;0.4 mg in 3 and 4 weeks,once in the morning and once in the evening;0.4 mg in 5 and 6 weeks,three times a day. If the treatment of tinnitus was invalid,then the gradual withdrawl was conducted by twice a day for continuous 3 d,0.4 mg each time;then once a day,0.4 mg each time,for continuous 3 d. The responders were maintained 12 weeks,and gradual withdrawal was conducted,and followed by follow-up for 3 months. The clinic data was observed,including the clinical efficacy,tinnitus disability scale（THI）score,visual analogue scale（VAS）score,tinnitus loudness（TI）and incidence of adverse reactions before and after treatment. RESULTS：The effective rate was 66.67%;after treatment,the scores of THI and VAS,and TI were significantly lower than before,with significant differences（P〈0.05）. There were no obvious adverse reactions during treatment. CONCLUSIONS：The alprazolam by progressive dose increasing has obvious efficacy in the treatment of chronic tinnitus,with good safety.