苦碟子注射液联合前列地尔治疗后循环缺血性眩晕的临床观察

Clinical Observation of Kudiezi Injection Combined with Alprostadil in the Treatment of Posterior Circulation Ischemic Vertigo

目的：观察苦碟子注射液联合前列地尔治疗后循环缺血性眩晕的临床疗效和安全性。方法：180例后循环缺血患者随机均分为A、B、C组。所有患者均给予拜阿司匹林、阿托伐他汀、营养神经、降压、降糖等常规治疗。在此基础上,A组患者给予前列地尔注射液10μg,加入0.9%氯化钠注射液100 ml中,静脉滴注,每日1次＋苦碟子注射液30 ml,加入0.9%氯化钠注射液250 ml中,静脉滴注,每日1次;B组患者给予前列地尔注射液（用法用量同A组）;C组患者给予苦碟子注射液（用法用量同A组）。各组患者疗程均为14 d。观察各组患者的临床疗效,治疗前后左侧椎动脉（LVA）血流速度、右侧椎动脉（RVA）血流速度、基底动脉（BA）血流速度,各脑电波绝对潜伏期（PL）及峰间潜伏期（IPL）的变化及不良反应发生情况。结果：A组患者总有效率显著高于B、C组,差异有统计学意义（P〈0.05）。治疗后,各组患者LVA、RVA、BA血流速度均显著高于同组治疗前,且A组高于B、C组;PL-Ⅰ、PL-Ⅲ、PL-Ⅴ、IPL-Ⅰ~Ⅲ、IPL-Ⅲ~Ⅴ均显著低于同组治疗前,且A组低于B、C组,差异均有统计学意义（P〈0.05）;但B、C组两组间比较差异均无统计学意义（P〉0.05）。各组患者治疗期间均未见明显不良反应发生。结论：苦碟子注射液联合前列地尔治疗后循环缺血性眩晕较单用苦碟子注射液或前列地尔疗效更显著,且安全性较好。

OBJECTIVE：To observe the clinical efficacy and safety of Kudiezi injection combined with alprostadil in the treatment of posterior circulation ischemic vertigo. METHODS：Totally 180 patients with posterior circulation ischemia were randomly divided into group A,group B and group C. All patients were given aspirin,atorvastatin,nutrition nerve,antihypertensive,hypoglycemic and other conventional treatment. On this basis,group A was given Alprostadil injection 10 μg,adding into 0.9% Sodium chloride injection 100 ml,iv,once a day;Kudiezi injection 30 ml,adding into 0.9% Sodium chloride injection 250 ml,iv,once a day. Group B was given Alprostadil injection（the same usage as group A）;group C was given Kudiezi injection（the same usage as group A）. The course was 14 d. The clinic data was observed,including clinical efficacy;blood flow velocity in left vertebral artery（LVA）,blood flow velocity in right vertebral artery（RVA）,blood flow velocity of basilar artery（BA）,changes of peak latency（PL）and incubation period latency（IPL）before and after treatment;and the incidence of adverse reactions. RESULTS：The total effective rate in group A was significantly higher than group B and C,with significant difference（P〈0.05）. After treatment,the blood flow velocity of LVA,RVA and BA in each group were significantly higher than before,group A was higher than group B and C;PL-Ⅰ,PL-Ⅲ,PL-Ⅴ,IPL-Ⅰ-Ⅲ and IPL-Ⅲ-Ⅴ were significantly lower than before,group A was lower than group B and C,with significant differences（P〈0.05）;however,there were no significant difference between group B and C（P〉0.05）. There were no obvious adverse reactions during treatment. CONCLUSIONS：Kudiezi injection combined with alprostadil has better efficacy than only Kudiezi injection or alprostadil in the treatment of posterior circulation ischemic vertigo,with good safety.