胃癌术后超声药物透入联合针灸治疗促肠功能恢复及IL-35、miRNA-488意义的研究

The significance of intestinal function recovery under the treatment of IL-35 and miRNA-488 in postoperative gastric cancer drug phonophoresis combined with acupuncture

目的探讨超声药物透入治疗联合针灸在胃癌术后促进胃肠道功能恢复中的作用。方法将79例胃癌术后患者随机分为实验组和对照组,在综合治疗方法相同的情况下,实验组加用超声药物透入联合针灸治疗,观测两组患者血清IL-35、miRNA-488,腹围变化,肠鸣音恢复、肛门排气、排便等胃肠功能恢复情况,以及住院时间。结果术后120 h实验组血清IL-35、miRNA-488较对照组下降明显(P<0.05)。术后48 h、72 h、96 h及120 h时实验组患者的腹围减小速度快于对照组,腹围变化值比较差异有统计学意义(P<0.05);实验组在术后120 h时腹围变化进入平台期,即腹围基本恢复正常,比对照组缩短约24 h。肠鸣音恢复时间、肛门初次排气排便时间两组比较也具有统计学意义(P<0.05)。两组24 h腹围变化值、住院时间相比,差异无统计学意义(P>0.05)。结论超声药物透入联合针灸治疗可促进胃癌术后患者肠鸣音恢复及排气排便,减轻腹胀,加快胃肠功能恢复。血清IL-35、miRNA-488可评估超声药物透入联合针灸治疗的疗效。

Objective To investigate the drug phonophoresis combined acupuncture promoting gastrointestinal function recovery after operation in gastric cancer. Methods 79 cases of postoperative gastric cancer patients were randomly divided into experimental group and control group,under the comprehensive treatment of the same circumstance,the experimental group were used drug phonophoresis combined with acupuncture alone.Upon the observation of two groups of patients,serum IL-35,miRNA-488,abdominal circumference changes,bowel sound recovery,anal exhaust defecation gastrointestinal function recovery and the length of hospital stay were analyzed accordingly. Results The serum IL-35,miRNA-488 in experimental group decreased significantly than that of the control group,abdominal circumference changes after treatment 48 h,72 h,96 h and 120 h and a two set of recovery time of bowel sound comparison,were statistically significant（ P〈 0. 05）,abdominal circumference and after treatment,changes in 24 h and the length of hospital stay between the two groups had no significant difference（ P〉 0. 05）. Conclusions Drug phonophoresis combined with acupuncture can accelerate the bowel sound recovery along with the recovery of gastrointestinal function,also can reduce exhaust defecationtime,abdominal distension of postoperative gastric cancer patients. The serum levels of IL-35,miRNA-488 can evaluate the therapeutic effect of ultrasonic medicine penetration.