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siRNA干扰雄激素受体相互作用蛋白HSPBAP1对人前列腺癌PC3细胞恶性表型的影响 被引量：1

The effect study of siRNA against HSPBAP1 in prostate cancer cell line PC3
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摘要 目的探讨siRNA干扰雄激素受体相互作用蛋白HSPBAP1对前列腺癌PC3恶性表型的影响。方法siRNA干扰PC3细胞HSPBAP1的表达，检测细胞增殖、克隆形成、细胞周期及迁移和侵袭的变化。结果siHSPBAP1组与对照组相比，增殖能力、克隆形成能力、迁移和侵袭能力显著减弱（P〈0．05），G0／G1期细胞数增多，S期和G2／M期细胞数显著减少（P〈0．05）。结论干扰HSPBAP1能够抑制前列腺癌PC3细胞的恶性表型。 Objectives To investigate the effect of siRNA against HSPBAP1 in prostate cancer cell line PC3. Methods Detecting cell proliferation, colony formation, cell cycle, migration and invasion in control and siHSBAP1 PC3 ceils. Results Knockdown of HSBAP1 inhibits cell proliferation, colony formation, migration and invasion and significantly induces G0/G1 arrest. Conclusions Knockdown of HSPBAP1 inhibits the malignant phenotype of prostate cancer cell line PC3.
作者 周建新 莫希玲 陈光彪 叶绍强 黎俊强
机构地区 东莞常平医院泌尿外科
出处 《国际泌尿系统杂志》 2015年第4期513-515,共3页 International Journal of Urology and Nephrology
关键词 前列腺肿瘤 受体 雄激素 RNA 小分子干扰 Prostatic Neoplasms Receptors, Androgen RNA, Small Interfering
分类号 R737.25 [医药卫生—肿瘤]
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参考文献12

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国际泌尿系统杂志
2015年 第4期

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