系统性红斑狼疮合并甲状腺功能异常的临床分析

Thyroid disfunctions in systemic lupus erythematosus

目的探讨系统性红斑狼疮（SLE）与甲状腺疾病之间的相关性。方法以186例完善甲状腺功能检查的SLE患者为研究对象，并以200例健康体健人群为对照组，比较甲状腺功能异常情况，甲状腺球蛋白抗体TGAb及抗甲状腺过氧化物酶TPOAb阳性率以及评估狼疮临床活动度。结果①甲状腺功能异常在SLE组发生率为28．5％，显著高于对照组7％，差异具有统计学意义（P〈0．05）；②SLE组TGAb阳性率16．7％，TPOAb阳性率25．8％，高于对照组中TGAb阳性率6％，TPOAb阳性率9％，两组差异具有统计学意义（P〈0．05）；③SLE组行SLEDAI评分，甲状腺功能正常组（8．2±4．7）分，甲状腺功能异常组（7．9±5．8）分，两组间差异无统计学意义（P〉O．05）；④甲状腺抗体阳性组SLEDAI评分（8．3±5．7）与抗体阴性组（7．9±6．4）相比，两组间差异无统计学意义（P〉0．05）。结论甲状腺功能异常、甲状腺抗体阳性在SLE患者中有较高的发病率，但与狼疮疾病活动无明显相关性，SLE患者随访中需常规行甲状腺功能检查，重视甲状腺疾病诊治。

Abstract Objectives To Explore the association between systemic lupus erythematosus and thyroid disease. Methods The study group included 186 SLE patients who were treated in the hospital and completed thyroid function tests, while the control group included 200 healthy people. Thyroid dysfunction, positive rate of TGAb, TPOAb had been compared and clinical activity of lupus had been assessed. Results ①The prevalence of thyroid dysfunction was 28.5% in the SLE group and 7 % in control group （ P 〈 0.05 ） ; ②The positive rate of TGAb is 16. 7% , the rate of TPOAb is 25.8%, in contrast, only 6% and 9% in control group（ P 〈 0.05 ） ; ③No significant difference were abserved with regard to SLEDAI score between thyroid disfunction group and normal group in SLE patients（ P 〉 0.0） ;④SLEDAI score had no statstically significant between thyroid antibody positive group and neg-ative group（ P 〉 0.05 ）. Conclusions Thyroid dysfunction and positive thyroid antibody are commom in SLE patients, but there is no significant association with lupus disease activity. It is essential to test thyroid function in the follow - up of SLE patients, and pay attention to diagnosis and treatment of thyroid disease.