依那普利叶酸片治疗H型高血压临床疗效观察

Clinical efficacy of enalapril-folic acid tablets in treatment of H-type hypertension

目的观察并探讨依那普利叶酸片治疗H型高血压的临床疗效。方法将在我院接受治疗的72例H型高血压患者,随机平均分为两组,观察组患者采用口服马来酸依那普利叶酸片进行治疗,对照组患者则口服马来酸依那普利片进行治疗,对两组患者的治疗60d后的临床效果进行观察和比较。结果经治疗后,观察组的舒张压、收缩压及Hcy水平均明显低于对照组,且差异具有显著性(P<0.05)。随访期间观察组心脑血管事件发生率约为8.33%,对照组心脑血管事件发生率约为25.00%,两组心脑血管事件发生率差异具有显著性(P<0.05),且观察组明显低于对照组。结论依那普利叶酸片可有效治疗H型高血压,临床疗效显著优于单独应用依那普利治疗,值得临床医生推广应用。

Objective To observe and investigate the clinical efficacy of enalapril- folic acid tablets in the treatment of H-type hypertension. Methods A total of 72 patients with H-type hypertension admitted to our hospital were randomly divided into two groups. Patients in the observation group were treated with oral enalapril maleate-folic acid tablets, whereas patients in the control groups were treated with oral enalapril maleate tablets. The clinical outcomes of patients from the above two groups after 60 days of treatment were observed and compared. Results After treatment, the diastolic and systolic pressure and homoeysteine （Hcy） level of the observation group were significantly lower than those of the control groups （P〈0.05）. During follow-up, the incidence of cardiovascular and cerebrovascular events was about 8.33% in the observation group, which was significantly higher than that in the control group （25.00%） （P〈0.05）. Conclusion Enalapril-folic acid tablets could treat H-type hypertension effectively, and their clinical efficacy is significantly superior to enalapril tablets alone. Enalapril-folic acid tablets are worthy of clinical recommendation.