摘要
骨质疏松症（0P）主要是因为骨重塑过程平衡被打破，骨形成与骨吸收过程中后者占主导地位，导致骨量减少、骨微结构破坏、骨折概率增大的一种严重危害患者生命健康的骨代谢疾病。大量研究表明，酪蛋白激酶2相互作用蛋白1（CKIP-1）在骨组织增殖、分化过程中起重要作用，其主要与Smad泛素调节因子1（Smurf1）相互作用进而影响骨代谢，从而改变骨质疏松的发生和发展。主要概述CKIP-1及其对骨组织成骨分化方向的影响及其机制，并对相关研究进行展望，为今后骨科相关疾病的临床治疗提供新的思路和方法。
Osteoporosis （OP） is one of the bone metabolic diseases which seriously harms the health and lives of people. The main cause of OP is that the balance between bone formation and bone absorption, i.e. the balance of the bone remodeling process, is no longer exist. When the bone absorption dominates the process, it will lead to osteopenia, destruction of bone microstructure and increased rate of fracture. Previous studies have shown that casein kinase 2-interacting protein-1 （CKIP-1） plays an important role in the process of bone tissue proliferation and differentiation. It mainly interacts with Smad ubiquitination regulatory factor 1 （Smurf 1） to affect bone metabolism. This review analyzes and summarizes the impact of CKIP-1 on bone tissue osteogenic differentiation direction and its mechanism, which may provide new idea and research orientation for future clinical treatment of osteoporosis.
出处
《国际生物医学工程杂志》
CAS
2015年第3期176-178,共3页
International Journal of Biomedical Engineering
基金
国家自然科学基金资助项目（31370942）
