硫酸特布他林与硫酸沙丁胺醇治疗高龄慢性阻塞性肺疾病急性加重期的疗效对比

Comparative Study on Effects of Terbutaline Sulfate and Salbutamol Sulfate in Treating Acute Exacerbation of Elderly Chronic Obstructive Pulmonary Disease

目的比较硫酸特布他林与硫酸沙丁胺醇治疗高龄慢性阻塞性肺疾病急性加重期(AECOPD)的临床疗效。方法将医院老年病科收治的104例高龄AECOPD患者随机分为A组和B组,各52例。两组患者均进行常规治疗,A组和B组分别给予硫酸特布他林和硫酸沙丁胺醇雾化吸入治疗。结果两组患者动脉血气分析和肺功能指标在雾化治疗30 min后均较治疗前有明显改善(P<0.05);治疗后8 h,B组第1秒用力呼气容积(FEV1)与呼气峰流速(PEF)下降明显,与A组比较,有显著性差异(P<0.05);连续治疗7 d后,A组临床总有效率为94.23%,与B组的96.15%比较,差异无显著性(P>0.05);A组不良反应发生率为1.92%,显著低于B组的7.69%(P<0.05)。结论硫酸特布他林与硫酸沙丁胺醇治疗高龄AECOPD的疗效相当,但硫酸特布他林改善患者肺功能指标更稳定持久,且不良反应发生率更低,建议高龄AECOPD患者可优先选用硫酸特布他林。

Objective To compare the clinical effects between terbutaline sulfate and salbutamol sulfate in treating acute exacerbation of chronic obstructive pulmonary disease（ AECOPD）. Methods Totally 104 patients with AECOPD in the geriatric department of the hospital were randomly divided into the terbutaline sulfate group（ group A） and salbutamol sulfate group（ group B）,52 cases in each group. The two groups were performed the routine therapy. The group A and B were given terbutaline sulfate and salbutamol sulfate atomization inhalation respectively. Results The arterial blood gas analysis and pulmonary function indexes at 30 min after atomization therapy in the two group were significantly improved compared with before treatment（ P〈0. 05）,but FEV1 and PEF at 8 h after treatment in the group B was decreased significantly,the difference compared with the group A had statistically significant difference（ P〈0. 05）; the total clinical effective rate after continuous 7 d treatment was 94. 34% in the group A and 96. 15% in the group B,the difference between the two groups had no statistical significance（ P〉0. 05）; the incidence rate of adverse reactions in the group A was1. 92%,which was significantly lower than 7. 69 % in the group B（ P〈0. 05）. Conclusion Terbutaline sulfate and salbutamol sulfate for treating elderly AECOPD have equivalent effect,but terbutaline sulfate improves the lung function indexes more stable and more persistent; moreover the incidence rate of its adverse reaction rate is much lower. It is suggested that terbutaline sulfate be preferred for elderly patients with AECOPD.