南海红树林内生真菌Aspergillus sp.9H次级代谢产物的研究

Secondary Metabolites of Mangrove Endophytic Fungus Aspergillus sp. 9H in the South China Sea

对南海红树林内生真菌Aspergillus sp.9H的次级代谢产物进行研究。利用土豆培养基对菌种进行培养,综合采用多种柱层析技术从Aspergillus sp.9H的次级代谢产物中分离得到了5个单体化合物,运用质谱、核磁等现代波谱技术鉴定其结构分别为brefeldin A(1),methoxyvermistatin(2),6-demethylvermistatin(3),purpurester A(4)和十一烷酸甘油酯(5)。其中化合物2,3,4均为首次从曲霉属海洋真菌中分离得到。

Seven compounds,including brefeldin A（ 1）,methoxyvermistatin（ 2）,6- demethylvermistatin（3）,purpurester A（4）,and glyceroll-hendecanoate（5）,were isolated from the mangrove endophytic fungus Aspergillus sp. 9H,obtained from the Kandeliacandel（ Linn.） Druce,collected from Yangjiang,Guangdong. Their structures were identified through mass analysis and NMR spectroscopy.Compounds 2,4,5 were isolated from marine fungus Aspergillus sp. for the first time.