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松弛素在生殖系统中的生物学作用 被引量：5

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摘要 松弛素（relaxin）最初是由Hisaw等人从猪血清中提取出的能松弛骨盆韧带的多肽类激素,＂松弛素＂由此得名.松弛素在人的生殖系统及非生殖系统中均发挥重要作用,作为生殖相关激素,松弛素在妊娠早期促进子宫内膜蜕膜化,辅助胚胎种植和胎盘生长;在妊娠中晚期扩张外周血管,提高胎盘血流供应,抑制妊娠期间子宫肌的收缩以利于妊娠的维持;在妊娠足月时松弛盆腔结缔组织以利于分娩.松弛素对人体其他系统也有作用.本文对松弛素在生殖系统中的生理学作用和其与疾病的关系进行综述如下.
作者 王丁然 王永清 乔杰
机构地区 北京大学第三医院妇产科
出处 《中华医学杂志》 CAS CSCD 北大核心 2015年第25期2036-2038,共3页 National Medical Journal of China
基金 国家自然科学基金（81450056）
关键词 生殖系统 松弛素 生物学作用 生殖相关激素 妊娠早期 多肽类激素 妊娠中晚期 生理学作用
分类号 R339.2 [医药卫生—人体生理学]
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参考文献26

  • 1Kong RC, Bathgate RA, Bruell S, et al. Mapping key regions of the RXFP2 low-density lipoprotein class-A module that are involved in signal activation [ J ]. Biochemistry, 2014,53 ( 28 ) : 4537-4548.
  • 2Feugang JM, Greene JM, Willard ST, et al. In vitro effects of relaxin on gene expression in porcine cumulus-oocyte complexes and developing embryos [ J ]. Reprod Biol Endocriuol, 2011,9 : 15.
  • 3Bastu E, Gokulu SG, Dural O, et al. The association between follicular fluid levels of cathepsin B, relaxin or AMH with clinical pregnancy rates in infertile patients [ J ]. Eur J Obstet Gynecol Reprod Biol, 2015,187 : 30 -34.
  • 4Vandevoort CA, Mtango NR, Latham KE, et al. Primate preimplantation embryo is a target for relaxin during early pregnancy[J]. Fertil Steril,2011,96( 1 ) :203-207.
  • 5Braun BC, Vargas A, Jewgenow K. The molecular detection of relaxin and its receptor RXFP1 in reprocluctive tissue of Fells catus and Lynx pardinus during pregnancy [ J ]. Reproduction, 2012,143 (3) :399-410.
  • 6Einspanier A, Lieder K, Husen B, et al. Relaxin supports implantation and early pregnancy in the marmoset monkey [ J ]. Ann N Y Acad Sci ,2009,1160 : 140-146.
  • 7Heng K, Ivell R, Wagaarachchi P, et al. Relaxin signalling in primary cultures of human myometrial cells [ J ]. Mol Hum Reprod, 2008,14 ( 10 ) : 603-611.
  • 8Sherwood OD, Downing SJ, Guico-Lamm ML, et al. The physiological effects of relaxin during pregnancy: studies in rats and pigs[J]. Oxf Rev Reprod Bio1,1993,15:143-189.
  • 9Conrad KP, Davison JM. The renal circulation in normal pregnancy and preeclampsia: is there a place for relaxin? [ J ]. Am J Physiol Renal Physiol,2014,306(10) :F1121-F1135.
  • 10Anand-Ivell R, Dai Y, Ivell R. Neohormones as biomarkers of reproductive health[ J]. Fertil Steri1,2013,99 (4) : 1153-1160.

二级参考文献23

  • 1Liu J, Feng ZC, Wu J. The incidence rate of premature rup- ture of membranes and its influence on fetal - neonatal health., a report from China's Mainland. Journal of tropical pediatrics, 2010, 56.. 36-42.
  • 2Getahun D, Ananth CV, Oyelese Y, et al. Acute and chronic respiratory diseases in pregnancy: associations with spontane- ous premature rupture of membranes. J Matern Fetal Neo- natal Med, 2007, 20: 669-675.
  • 3Vogel I, Salvig JD, Seeher NJ, et al. Association between raised S- relaxin during the eighteen gestation week and very preterm delivery. Am J Obstet Gynecol, 2001, 184 390 - 393.
  • 4Bogie LV, Yamamoto SY, Millar LK, et al. Developmenta regulation of the human relaxin genes in the decidua and pla- centa., overexpression in the preterm premature rupture of the fetal membranes. Biol Reprod, 1997, 57: 908- 920.
  • 5Vishal P, Kellie J, Robert M, et al. The force required to rupture fetal membranes paradoxically increases with acute in vitro repteated stretching. Am J Ohstet Gynecol, 2007, 196: 165- 167.
  • 6Goldenberg RL, Culhane JF, Iams JD, et al. Eepidemiology and causes of preterm birth. Lancet, 2008, 371: 75- 84.
  • 7Bani D. Relaxin: a pleiotropic hormone. Gen Pharmacol, 1997, 28, 13-22.
  • 8Byant - Greenwood GD, Schwabe C. Human relaxin: chem- istry and biology. EndocrRev, 1994, 15: 5-26.
  • 9I Bell RJ, Eddie LW, Lester AIR, et. al. Relaxin in human pregnancy serum measured with an homologous radioimmu- noassay. Obstet Gynecol, 1987, 69: 585-589.
  • 10Lafayette RA, Hladunewich WA, Derby G, et al. Serum re- laxin levels and kidney function in late pregnancy with or without preeclampsia. ClinNephrol, 2011, 75: 226-232.

共引文献5

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中华医学杂志
2015年 第25期

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