SLE患者血清suPAR水平与疾病活动度的相关性分析

Correlation analysis between soluble urokinase plasminogen activator receptor levels and the severity of disease activation in patients with systemic lupus erythematosus

目的探索系统性红斑狼疮(SLE)患者血清可溶性尿激酶型纤溶酶原激活物受体(suPAR)水平与其疾病活动度的关系。方法采用ELISA方法测定74例SLE患者和20例健康对照血清suPAR水平,并分析suPAR水平与补体C3、补体C4、SLE疾病活动度指数(SLEDAI)的相关关系。结果与健康对照组比较,SLEDAI积分在10分以上的SLE患者血清suPAR水平明显升高,差异有统计学意义,SLE患者血清suPAR水平与疾病活动度存在相关关系,suPAR水平与SLEDAI积分呈正相关,与补体C3、补体C4呈负相关;SLEDAI积分小于10分的轻度疾病活动组的SLE患者血清suPAR水平低于积分在10分以上的中重度疾病活动组,差异有统计学意义。结论 SLE患者血清suPAR可以作为一种新的生物学标志来反映SLE的疾病活动度;中重度疾病活动组的suPAR水平与轻度疾病活动组的suPAR水平的差异有统计学意义。

In order to explore the relationship between soluble urokinase plasminogen activator receptor （suPAR） levels and the severity of disease activation in patients with systemic lupus erythematosus （SLE）, the serum suPAR levels in 74 patients with SLE and 20 healthy people were measured by ELISA, and the correlation between suPAR levels and the severity of SLE disease activation was analyzed with SPSS software. Data showed that the serum suPAR levels in SLE patients with SLE disease activity index （SLEDAI） score equal to or more than 10 were elevated statistically as compared with normal control subjects; and serum suPAR level was positively correlated with SLEDAI, but negatively correlated with complements C3, C4. Additionally, the suPAR level of the SLE group with SLEDAI score less than 10 was significantly lower than that of the SLE group with SLEDAI score equal to or more than 10. In conclusion, serum suPAR levels can reflect the disease severity of patients with SLE; there is significant difference of suPAR level between the SLE group with SLEDAI score less than 10 and the SLE group with SLEDA1 score equal to or more than 10.