HLA-B关联转录因子3在免疫相关疾病中的作用

Role of HLA-B associated transcript 3 in immune diseases

HLA-B关联转录因子3(HLA-B associated transcript3,BAT3/Scythe/BAG6)是BAG蛋白家族一员.近几年发现他除调控细胞周期外还以多种机制参与机体免疫调控,通过促进树突状细胞(dendritic cells,DCs)成熟、巨噬细胞的活性及抗原提呈细胞(antigen presenting cells,APCs)上主要组织相容性复合体(major histocompatibility complex,MHC)-Ⅱ的表达来调节慢性炎症;细胞内表达的BAT3抑制Tim-3(T cell immunoglobulin and mucin domain 3)介导的辅助性T细胞(T helper Cells,Th)1凋亡,加重自身免疫性疾病;肿瘤细胞分泌的BAT3依赖天然杀伤细胞(natural killer cell,NK)p30调节NKs的毒性,参与肿瘤细胞免疫逃逸和肿瘤排斥.进一步了解BAT3及其与免疫调控和免疫相关疾病的研究进展有利于为免疫相关疾病的治疗带来新的方法.

HLA-B associated transcript 3（BAT3/Scythe/BAG6） is a member of the BAG protein family which can regulate the cell cycle.Recently,BAT3 has also been identified to have immunoregulatory function through kinds of mechanisms.First,BAT3 can promote the maturation of dendritic cells（DCs）,the activity of macrophages and the expression of major histocompatibility complex（MHC）-II on antigen presenting cells（APCs） to regulate chronic inflammation.Second,BAT3 can suppress T cell immunoglobulin and mucin domain 3（Tim-3）-mediated cell death and exhaustion of T helper cell type 1（Th1）to exacerbate autoimmune diseases.Finally,BAT3 can regulate the cytotoxicity of natural killer cells（NKs） in a NKp30-dependent manner to play a part in tumor immune evasion and tumor rejection.Further details about BAT3 and its involvement in immunity and immunity-associated diseases will benefit the novel strategy for treatment of immune diseases.