原发性肝癌研究当前面临的挑战

Current challenges to primary liver cancer research

原发性肝癌是常见恶性肿瘤,发病率和死亡率均呈升高趋势。近年来原发性肝癌临床研究不断取得长足进展,但仍面临严峻挑战。重点评述原发性肝癌相关的分子分型和干细胞基础研究、病理和临床诊断、临床分期、外科治疗、局部区域治疗、分子靶向治疗、系统化疗、门静脉癌栓治疗、抗病毒治疗、肝内胆管癌诊治及多模式综合治疗等方面当前的进展和研究难点,探讨进一步提高原发性肝癌临床研究水平的发展前景。

Primary liver cancer is a common malignancy with increasing incidence and mortality. Remarkable progress has been made in the clinical research on liver cancer,but challenges to further improvement are still rigorous. This article reviews the progress and difficulties of primary liver cancer study from the following aspects： molecular classification and stem cell biology,pathological and clinical diagnosis,clinical staging,surgical treatment,loco- regional treatment,molecular targeted therapy,systemic chemotherapy,management of portal vein tumor thrombus,antiviral therapy,diagnosis and treatment of intrahepatic cholangiocarcinoma,and multimodality treatment. The future strategies to further improve primary liver cancer study are also investigated.