武山县苗丰村居民肝损害情况横断面调查分析

Investigation of impairment of liver function in local residents of Miaofeng Village,Wushan County,China

目的调查甘肃省武山县马力镇苗丰村居民肝损害状况,分析居民肝损害的可能原因,为不明原因肝损害的病因研究提供依据。方法对苗丰村居民进行肝功能普查、流行病学调查;对肝功能异常者进行血清学检测;对居民饮用水及环境土壤行砷、铬、硒等微量元素的检测。结果苗丰村居民中血清ALT异常者占检测总数的23.8%,AST异常者占检测总数的10.7%;HBs Ag阳性11例,脂肪肝3例。土壤中微量元素硒缺乏。结论部分苗丰村居民存在肝损害。环境土壤微量元素硒缺乏可能是导致居民肝损害的原因之一。

Objective To assess the impairment of liver function and investigate possible causes in local residents in Miaofeng Village,Mali Town,Wushan County,Gansu Province,China,and to provide a basis for the etiological study of idiopathic liver damage. Methods The residents in Miaofeng Village were screened for liver function and an epidemiological study was conducted. Serological testing was performed for those with abnormal screening results. Trace elements in drinking water and soil such as arsenic,chromium,and selenium were also tested. Results Of all residents,23. 8% and 10. 7% showed abnormal levels of alanine aminotransferase and aspartate aminotransferase,respectively. Positivity of HBs Ag was detected in 11 cases,fatty liver was identified in 3 cases,and absence of selenium in soil was also confirmed. Conclusion A proportion of local residents in Miaofeng Village have impaired liver function and the absence of selenium in soil may be a contributing factor to this phenomenon.