肝细胞癌合并门静脉癌栓治疗新进展

New progress in treatment of hepatocellular carcinoma with portal vein tumor thrombus

门静脉癌栓是肝细胞癌晚期患者常见表现之一,是导致严重并发症的决定性因素,预后极差。随着分子生物学及影像学技术的发展,外科手术切除、介入栓塞化疗、放射治疗、各种消融治疗、分子靶向治疗等手段,无论单一应用还是综合治疗均取得了丰硕成果,但目前仍缺乏合理有效的治疗规范。对近些年来关于肝细胞癌合并门静脉癌栓的治疗新进展做出总结,希望能为今后治疗方案的规范化提供参考。

Portal vein tumor thrombus（ PVTT） is one of the common manifestations in patients with advanced hepatocellular carcinoma（ HCC）. It is the decisive factor leading to severe complications and causes extremely poor prognosis. With the development of molecular biology and imaging techniques,both single and combined therapy modalities,including surgical resection,embolization and chemotherapy,radiation therapy,a variety of ablation therapies,and molecular targeted therapy,have achieved substantial progress. However,there are no guidelines for reasonable and effective treatments. In this paper,new progress in the treatment of HCC with PVTT in recent years is summarized to provide a standardized approach for future treatment options.