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肿瘤 miRNAs 调控机制的研究进展与展望 被引量：18

Outlook and advances in research on miRNAs in cancer
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摘要 微小RNA(micro RNAs,miRNAs)是一类不同于mRNA的非蛋白编码的小RNA,其通过结合靶mRNA的3′非翻译区(3′untranslated region,3′UTR),抑制靶mRNA的翻译或降解靶mRNA。miRNA在肿瘤发生、生长、迁移与侵袭过程中发挥了重要作用。miRNA的调控与其在肿瘤中的功能密切相关。竞争性内源性RNA(competing endogenous RNA,ceRNA)、环状RNA(circular RNA,circRNA)及RNA结合蛋白(RNA binding protein,RBP)参与了miRNA靶基因的表达调控,可能是miRNA在不同肿瘤组织及细胞中功能多样化与复杂化的原因之一。研究miRNA在特定细胞中网络调控机制的新技术是未来的新方向。 microRNA （miRNA）is a kind of non-protein-coding small RNA that is different from mRNA. miRNAs interact with the 3’ untranslated region （3’UTR ）of the target mRNA,resulting in either complete degradation or translational inhibition of the target mRNA.miRNAs play a vital role in tumorigenesis,growth, migration and invasion.The regulation of miRNA is closely related to its function in cancer.Competing endogenous RNA （ceRNA）,circular RNA （circRNA）and RNA binding protein （RBP）as regulatory molecules are involved in the expression regulation of target genes.It may be one reason why the miRNA has complicated and diversified functions in diverse cancer tissues or cancer cells.The future direction of miRNA research is to study the latest technology to find the network control mechanism of miRNA in the specific cells.
作者 黄辰 刘利英 倪磊 宋土生
机构地区 西安交通大学医学部基础医学院细胞生物学与遗传学系 西安交通大学医学部生物医学研究实验中心
出处 《西安交通大学学报（医学版）》 CAS CSCD 北大核心 2015年第4期429-434,共6页 Journal of Xi’an Jiaotong University（Medical Sciences）
基金 国家自然科学基金资助项目(No.81171398) 中加健康研究合作计划资助项目(No.81161120549) 陕西省卫生科研资助项目(No.2014D75)~~
关键词 sncRNA MIRNA 表达调控 肿瘤 sncRNA miRNA sncRNA miRNA expression regulation tumor
分类号 R730 [医药卫生—肿瘤]
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参考文献63

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同被引文献152

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引证文献18

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西安交通大学学报（医学版）
2015年 第4期

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