宫外发育迟缓早产儿早期体格发育与IGF-Ⅰ相关性分析

Analysis of Relevance between Physical Development of Premature Infants with Extrauterine Growth Retardation and IGF-Ⅰ

目的:探讨宫外发育迟缓(EUGR)早产儿的早期体格发育与胰岛素样生长因子(IGF-I)的关系。方法:早产儿60例,分为EUGR组及非EUGR组,以同期收治的足月并正常出生的新生儿30例为对照组,所有新生儿于出生后7 d与2周时测量体格发育指标(体重、头围、身长),同时采集外周血测定血清中IGF-I水平;随访3月后测量2组早产儿体格发育指标,记录体重、身长及头围发育落后例数和计算体格发育指标增长情况,同时测定血清IGF-I水平,分析体格发育指标增长与IGF-I水平相关性。结果:早产儿7d、14d时体重、头围、身长、IGF-I水平均低于对照组(P<0.05),EUGR组早产儿7d、14d时体重较非EUGR组低(P<0.05);随访3月发现EUGR组早产儿体重、头围、身长及IGF-I水平低于非EUGR组(P<0.05),体重、身长及头围发育落后例数高于非EUGR组(P<0.01、P<0.01、P<0.05),体重增长速度、头围及身长增长均低于非EUGR组(P<0.05);EUGR组和非EUGR组IGF-I水平与体重增长速度、头围及身长增长均呈正相关(r=0.399、0.453、0.377、0.615、0.443、0.435,P<0.05)。结论:IGF-I水平变化与早产儿体格发育相关,EUGR早产儿更明显。

Objective： To investigate the relationship between early- stage physical development of premature infants with extrauterine growth retardation and IGF - I level. Methods： Sixty premature in- fants were divided into extrauterine growth retardation group （EUGR group, 31 cases） and non extrau- terine growth retardation group （non- EUGR group, 29 cases） , meanwhile 30 full -term normal in- fants hospitalized during the same period were selected as control group. The physical development in- dexes（weight, head circumference, height） were measured 7 days and 14 days after birth. Mean- while, the peripheral blood was collected and the IGF - I level of serum was determined. 3 months af- ter birth, the physical development indexes of premature infants in 2 groups were measured again, the retardation cases were recorded in terms of weight, head circumference and height and the growth of physical development index were calculated. Meanwhile, the IGF - I level of serum was determined and the relevance between growth of physical development indexes and IGF - I level was analyzed. Re- suits ： The weight, head circumference, height and IGF - I level of premature group infants were lower than their counterparts of full - term infants on their 7th day, 14ts day after birth. （ P 〈 0.05 ）. The weight of EUGR group was lower than that of non - EUGR group on their 7~ day, 14~s day after birth （P 〈 0.05 ）. The weight, head circumference, height and IGF - I level of EUGR group were signifi- cantly lower than their counterparts of non - EUGR group on their 90th day （ P 〈 0.05 ）. The growth rate of weight, head circumference and height of EUGR group were lower than those of non EUGR group. There was a positive correlation between IGF - I level and development speed of weight, head circumference, height（r = 0. 399, 0.453, 0.377, 0. 615, 0.443, 0.435, P 〈 0.05 ）. Conclusion ： IGF - I level is relevant to physical development of EUGR premature infants.