氨氯地平联合阿托伐他汀对高血压合并高血脂症患者的疗效

The Curative Effect of Amlodipine Combined with Atorvastatin in the Treatment of Hypertension with Hyperlipidemia

目的:探究氨氯地平联合阿托伐他汀在治疗高血压合并高血脂症中的临床疗效。方法:门诊治疗的高血压合并高血脂症患者200例,随机均分为观察组和对照组,观察组患者采用氨氯地平联合阿托伐他汀治疗,对照组患者采用氨氯地平进行治疗;观察两组患者治疗前后血压变化,比较治疗效果;同时比较两组患者治疗前后的低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、甘油三酯(TG)及胆固醇(TC),丙氨酸氨基转移酶(ALT)、血肌酐、血钾(K+)及血尿酸水平。结果:治疗后,观察组总有效率优于对照组,不良反应明显低于对照组(P<0.05),收缩压和舒张压较治疗前明显下降,观察组改善更明显(P<0.05);观察组患者LDLC、TG及TC水平较治疗前下降,而HDL-C升高,这些血脂成分改变优于对照组(P<0.05);观察组治疗后,血肌酐和血尿酸水平下降明显(P<0.05),与无变化的对照组间比较,差异有统计学意义(P<0.05)。结论:氨氯地平联合阿托伐他汀对高血压合并高血脂症患者的治疗效果优于单独使用氨氯地平。

Objective： To explore the curative effect of amlodipine combined with atorvastatin in the treatment of hypertension with hyperlipidemia. Methods：Two hundred cases of patients with hyperten- sion and hyperlipidemia were enrolled in the study. The patients were randomly divided into observa- tion group（ 100 cases） and control group （100 cases）. Observation group was treated with amlodipine and atorvastatin in combination therapy, and control group of patients treated with amlodipine alone. The change of blood pressure was observed and the curative effect was compared between two groups. Meanwhile, the levels of LDL- C, HDL- C, TG, TC, ALT, serum creatinine, serum potassium and blood uric acid were compared between observation group and control group before and after treatment. Resuits：Mter treatment, The total effective rate of observation group was higher than that of control group while incidence rate of untoward effect was lower than that of control group, and the difference was statistically significant between two groups （P 〈 0. 05 ）. Both systolic and diastolic pressures were significantly decreased in two groups after treatment, but the improvement was better in observation group （P 〈 0. 05 ）. After treatment, LDL - C, TG and TC levels in observation group were decreased while HDL - C level increased, and these changes of blood lipid levels were significantly better than those of control group （P 〈 0. 05 ）. Compared with control group, the level of serum creatinine and blood uric acid in observation group after treatment were significantly decreased （P 〈 0. 05 ）. Conclu- sion ： The curative effect of amlodipine combined with atorvastatin in the treatment of hypertension with hyperlipidemia is better than amlodipine alone.