老年高血压合并AECOPD血PINP、β-CTX的表达水平研究

The expression of serum PINP and β-CTX in elderly hypertension complicated with AECOPD

目的探讨血I型胶原氨基端前肽(PINP)和I型胶原羧基端肽β特殊序列(β-CTX)在老年高血压合并慢性阻塞性肺疾病急性期(AECOPD)中的表达。方法选择2011年1月至2013年12月124例老年高血压合并慢性阻塞性肺病(COPD)患者为研究对象。将124例患者按照COPD严重程度分为AECOPD期64例(急性加重组),COPD缓解期60例(缓解组),同期选择72例健康人群作为对照组。给予AECOPD患者促进骨形成药物治疗,检测受试者血清PINP、β-CTX含量,并对老年高血压合并AECOPD患者PINP、β-CTX的表达与年龄、烟龄、肺功能、体重指数(BMI)的关系进行相关性分析。结果急性加重组血清PINP、β-CTX含量明显低于缓解组和对照组,差异有统计学意义(P<0.01),缓解组PINP水平低于对照组,但β-CTX高于对照组,差异有统计学意义(P<0.01)。AECOPD患者经治疗后血清PINP、β-CTX水平明显较治疗前提高,差异有统计学意义(P<0.01)。老年高血压合并AECOPD血PINP表达与烟龄呈负相关(P<0.05),与FEV1%预计值、FEV1/FVC(%)呈正相关(P<0.05);血β-CTX表达与烟龄呈负相关(P<0.05),与FEV1%预计值、FEV1/FVC(%)呈正相关(P<0.05);血PINP和β-CTX表达之间呈正相关(P<0.05)。结论老年高血压合并AECOPD患者血PINP、β-CTX表达明显降低,患者骨质疏松症发病风险增大。

Objective To study expression of serum collagen type I N-terminal propeptide（PINP） and procollagen type I carboxy terminal peptide beta special sequence（ β- CTX） in elderly hypertension complicated with COPD. Methods Between 2011 January and 2013 December 124 cases of elderly patients with hypertension complicated with AECOPD were selected for the study. 124 patients in accordance with the severity of（chronic obstructive pulmonary disease）COPD were divided into acute exacerbation of COPD group with 64 cases,and COPD in remission stage group with 60 cases. 72 cases of healthy people were selected as control group. Serum PINP and β-CTX levels were tested and the relations between the various indexes and age, smoking, pulmonary function,body mass index（BMI） correlation were analyzed.Results Acute group serum PINP and beta CTX levels were significantly lower than those of the ease group and the control group（P〈0.01）. In the alleviating group, the serum PINP level was significantly lower than that of the control group, but the serum beta CTX level was significantly higher than that of the control group（ P〈0. 01）. In AECOPD patients after treatment the levels of serum PINP and beta CTX were significantly increased（ P〈0. 01）. In the elderly hypertension complicated with AECOPD group, the serum PINP level was negatively correlated with smoking（P〈0.05）,and were positively correlated with FEV1 % expected value, FEV1 / FVC（%）（P〈0.05）; Serum beta CTX expression was negatively correlated with smoking（P〈0.05）, and was positively correlated with FEV1 % expected value and FEV1 / FVC（ %）（ P〈0. 05）. The serum PINP level was positively correlated with beta CTX expression（ P〈0. 05）. Conclusion In elderly patients with hypertension complicated with AECOPD the serum levels of PINP and beta CTX were significantly low and could increase the risk of osteoporosis.