乙肝孕妇与正常孕妇同孕期血清AFU含量比较

Comparison of a-L-fucosidase(AFU) in hepatitis B and normal pregnant women at same stage of pregnancy

目的探讨对乙肝孕妇测定血清a-L-岩藻糖苷酶(AFU)的价值。方法选择2011年1月至2013年12月于广州市妇女儿童医疗中心产检的有慢性乙肝病史的孕妇共70例,根据晚孕期病情严重程度分为轻度乙肝组、中度乙肝组、重度乙肝组;正常孕妇组为同期我院产检的健康孕妇,无特殊病史;对照组为未孕妇女,均为同期本院体检健康未孕妇女。分别检测血清AFU含量并进行统计学分析。结果未孕组与正常孕妇组早孕期血清AFU比较差异无统计学意义(P>0.05),未孕组与乙肝孕妇组早孕期比较差异有统计学意义(P<0.05);同孕期乙肝孕妇血清AFU含量高于正常孕妇,差异均有统计学意义(P<0.05);乙肝孕妇组早、中、晚孕期AFU含量呈现升高,各孕期间比较差异有统计学意义(P<0.05);轻度、中度、重度乙肝孕妇组血清AFU在同孕期呈现升高,各病情间比较差异均有统计学意义(P<0.05)。结论妊娠期血清AFU含量增加且随孕周的增加而升高,但乙肝孕妇升高更为显著且随病情加重升高越明显,提示其对孕期病情评估有价值。

Objective To study the level of a-L-fucosidase（AFU） in hepatitis B pregnant women. Method Serum levels of AFU in non-pregnant women, hepatitis B pregnant women and normal pregnant women were detect. Results There were no significant differences in the AFU levels between non-pregnant women and normal pregnancy group（P〉0.05）; there were significant differences between non-pregnant women and hepatitis B pregnant group at the early stage of pregnancy（P〈0.05）. There were significant differences in the AFU levels between hepatitis B pregnant women and normal pregnant woman at same stages of pregnancy（ P〈0. 05）. There were significant differences in the AFU levels between different stages of pregnancy of hepatitis B pregnant women（P〈0.05）. Conclusion AFU levels in serum increases with pregnancy weeks and were higher in hepatitis B pragnant women than those of normal pregnant women and were rising along with patients condition,which would be good index for assessing abnormal pregnancy.