广州市育龄妇女TORCH筛查回顾性分析

The retrospective analysis of TORCH screening in reproductive-age women in Guangzhou

目的了解广州市育龄妇女外周血中的弓形体(TOX)、风疹病毒(RUB)、巨细胞病毒(CMV)、单纯疱疹病毒Ⅰ+Ⅱ型(HSV-Ⅰ+Ⅱ)及细小病毒(B19)抗体(合称为TORCH抗体)感染现状,为本地区的妇女保健及优生优育工作提供依据。方法选取2013年在广州市妇女儿童医疗中心进行孕前检查及早孕期妇女,应用ELISA方法检测外周血中的TORCH-Ig M和TORCH-Ig G,并对筛查阳性具有产前诊断指针的孕妇抽取胎血进行相关检测。结果TORCH-Ig M抗体总阳性率达1.94%,其中以人微小病毒B19-Ig M感染率最高,为3.71%。调查发现秋季为风疹病毒感染的相对高发期,其余病毒感染无明显季节性。TORCH-Ig G抗体总阳性率达60.01%,其中以CMV-Ig G的阳性率最高,达97.21%。胎血筛查中,TOX-Ig M、RUB-Ig M、CMV-Ig M、B19-Ig M均可筛查出阳性例数。结论广州市孕前和孕早期妇女TORCH感染率较高,积极进行监测以预防先天性TORCH感染非常必要。

Objective To study the positive rate of toxoplasm, rubella virus, cytomegalo virus, herpes simplex virus and human parvovirus B19（shortened for TORCH） infection in reproductive-age women of Guangzhou by enzyme linked immunosorbent assay（ELISA）,and provide the basis for health care and eugenics among women in local area. Methods TORCH-Ig M and TORCH-Ig G levels in blood plasma of reproductive-age women from January to December in 2013 were dedtermined by ELISA. In addition, the fetal blood serum was tested for pregnant women whose prenatal diagnosis index was positive. Results The total positive rate of TORCH-Ig M was 1.94%,and the highest one was human parvovirus B19-Ig M, 3.71%.The investigation suggest that autumn was the relatively high incidence period of rubella virus infection,and there was no obvious seasonal differences in other virus infection. The total positive rate of TORCH-Ig G was60.01%,and the highest one was cytomegalovirus-Ig G,97.21%.In fetal blood screening,all pathogens could be detected positive except herpes simplex virus. Conclusion The TORCH infection rate in reproductive-age women of Guangzhou is high,and it is necessary to monitor the TORCH infection in reproductive-age women actively in order to prevent congenital TORCH infection.