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2型糖尿病患者血清IGF-1、IGFBP-3水平与结直肠癌的关系 被引量：7

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摘要 目的探讨2型糖尿病患者血清胰岛素样生长因子1(IGF-1)、胰岛素样生长因子结合蛋白3(IGFBP-3)水平与结直肠癌的关系。方法选取本院确诊为2型糖尿病合并结直肠癌患者20例(A组),结直肠癌患者72例(B组),2型糖尿病患者45例(C组),健康体检者45例(D组),测定四组血清IGF-1、IGFBP-3水平,并计算IGF-1/IGFBP-3比值。结果四组间血清IGF-1水平、IGF-1/IGFBP-3总体差异有统计学意义(P<0.01),IGFBP-3水平四组总体间差异无统计学意义(P>0.05)。A组血清IGF-1、IGF-1/IGFBP-3水平高于B、C、D组(P<0.05),C组亦高于D组(P<0.05)。结论 2型糖尿病患者血清IGF-1增高,IGF-1/IGFBP-3的比值增高,罹患结直肠癌后可进一步使血清IGF-1水平及IGF-1/IGFBP-3的比值显著增高。
作者 曹宏 黄德芳 孙道崎 曹敏 黄璇 金春晖 刘超
机构地区 无锡市第三人民医院内分泌病科 无锡市第三人民医院检验科 无锡市中医院肿瘤科 江苏省中西医结合医院内分泌病科
出处 《江苏医药》 CAS 2015年第13期1577-1578,共2页 Jiangsu Medical Journal
关键词 2型糖尿病 结直肠癌 胰岛素样生长因子1 胰岛素样生长因子结合蛋白3
分类号 R587 [医药卫生—内分泌]
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参考文献8

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二级参考文献12

  • 1段琼红,王志刚,朱桂宝,卢祖洵,施侣元,聂绍发.血清IGF-1、IGFBP-3水平和大肠癌关系的Meta分析[J].中华流行病学杂志,2005,26(2):132-134. 被引量：11
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共引文献14

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二级引证文献54

江苏医药
2015年 第13期

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