LL-37在酒渣鼻发病机制中的研究进展

Research Advances of LL-37 in the Pathogenesis of Rosacea

酒渣鼻是一种天然免疫反应增强的炎症性皮肤病。LL-37是皮肤中天然免疫的重要效应分子,具有诱导新生血管和促进炎症反应的作用。LL-37在酒渣鼻皮损中高表达,参与酒渣鼻红斑、毛细血管扩张和炎性丘疹的形成。日光、毛囊蠕形螨等外界环境刺激通过多种途径上调LL-37的活性及分泌。LL-37与酒渣鼻的发病机制密切相关,是一种有前途的酒渣鼻治疗靶点。

Rosacea is an inflammatory skin disease characterized by accentuation of innate immune response. LL-37 is an important effector molecules of innate immunity in the skin, which ean induce angiogenesis and promote inflammation. The high expression of LL-37 in the lesions of rosacea contributes to erythema, telangiectasias and inflammatory papules of the disease. The activity and secretion of LL-37 was upregulated by sunlight, de- modex folliculorum and other external environmental stimuli through a variety of ways. LL-37 has an intimate association with the pathogenesis of rosacea, and serve as a promising treatment target for rosacea.