维生素D与慢性荨麻疹的研究进展

Relationship between Vitamin D and Chronic Urticaria

维生素D在机体固有免疫和获得性免疫中扮演着重要的角色,通过刺激Toll样受体,抑制炎症细胞因子的产生,调节Th细胞分化平衡。近年来的研究表明维生素D的水平与慢性荨麻疹相关。已有文献报道慢性荨麻疹患者维生素D水平下降,并与慢性荨麻疹症状严重程度相关,提示维生素D有可能参与了慢性荨麻疹的发病。本文就维生素D水平与慢性荨麻疹发病的国内外研究现状与进展作一综述。

Vitamin D plays key roles in innate and adaptive immunity through stimulating Toll-like receptors,inhibiting pro-inflammatory cytokine production, and regulating the balance of Th cell differentiation. Studies have shown a relationship between vitamin D levels and chronic urticaria. Many literatures have reported that peo- ple with chronic urticaria often have low levels of vitamin D, and the vitamin D levels are also associated with severity of chronic urticaria,which indicates that vitamin D may be involved in the pathogenesis of chronic ur- ticaria. This article reviews the research progress in the relationship between vitamin D and chronic urticaria in recent years.