双泵复苏术模型血流动力学的非线性机制

Nonlinear mechanism of the hemodynamics of AEI-cardiopulmonary resuscitation model

双泵复苏术是一种将体外反搏和主动按压放松以及吸气阻力阀相结合的复苏术。研究表明在心肺复苏按压的放松期间,下肢的体外反搏可以有效改善心肺复苏的血流动力学效果。基于体外反搏在双泵复苏术中占据的重要地位,从血流动力学基本理论出发,研究了双泵复苏术仿真过程中的血流动力学问题。对课题组成员建立的双泵复苏术数学模型进行简单介绍。该线性模型重点研究心肺复苏仿真问题中血管顺应性的非线性机制。基于原始模型,提出一套适用于仿真体外反搏血流动力学的非线性模型,并用动物实验数据进行验证。该动力学模型可以定量分析双泵复苏术的血流动力学效果。考虑下肢血管非线性血流动力学问题后,模型仿真的血流动力学优于原模型,并能够反映动物实验数据中升主动脉压曲线的主要生理特征。

AEI-cardiopulmonary resuscitation （AEI-CPR） is the resuscitation combined with enhanced external counter-pul- sation （EECP）, active compression-decompression CPR （ACD-CPR） and the impedance threshold valve （ITV）. The research showed that during the recoil phase of CPR, the EECP on lower limbs could improve hemodynamic effects of CPR. Because EECP plays an important role in AEI-CPR, the hemodynamic during the AEI-CPR was studied based on the basic principles of hemodynamics. The nonlinear mechanism of vascular compliance during the CPR was mainly studied. Based on the original model, a nonlinear model that was fit to be used in the simulation of the hemodynamic of EECP was developed. And the model was verified by the data of animal experiments. The model could quantitatively analyze hemodynamic effects of AEI-CPR. Regarding the nonlinear hemodynamics of lower extremity vessel, the hemodynamics of simulation is better than that of origin model. The simulated model can reflect the main physiological characteristics of the ascending aortic pressure curve obtained from animal experiments.