精氨酸刺激试验对胰岛β细胞功能评估的临床价值

The clinical value of arginine stimulation test for testing the function of islet β-cell

目的:观察并且评估精氨酸刺激试验(AST)对糖尿病患者胰岛β细胞功能的价值。方法:对我院内分泌科20名住院的2型糖尿病患者进行AST及标准馒头餐试验,评价其胰岛β细胞功能,评估AST的安全性、有效性及其临床价值。结果:AST中各个时间点的血糖差异无统计学意义(P=0.918);标准馒头餐试验后60、120 min血糖明显升高(P=0.000)。AST胰岛素曲线下面积、胰岛素均值、峰值与标准馒头餐胰岛素曲线下面积呈正相关。结论:对2型糖尿病患者进行AST来评估胰岛功能,与标准馒头餐试验具有一致性佳、血糖波动小的特点,是一种简单可行、方便、安全性好的糖尿病患者胰岛β细胞功能的评价方法。

Objective：To observe and assess the value of arginine stimulation test for testing the function of islet β-cell of patients with T2 DM.Methods：The function of islet β-cell of 20 hospitalized patients with type 2 diabetes was evaluated using arginine stimulation test and standard bread meal.Assess the safety and efficiency of arginine stimulation test and estimate its clinical value for patients with T2 DM.Results：There were no significant differences of blood glucose between each time point of arginine stimulation test（P=0.918）; And the plasma glucose levels of 60 min and 120 min after the standard bread meal test were significantly higher（P=0.000）.Insulin area under the curve,mean value,peak value of arginine stimulation test were positive correlation with insulin area under the curve of the standard bread meal test.Conclusion：Arginine stimulation test showed a superiority to assess islet function of patient with T2 DM,with the advantages of less impact on blood glucose,simpler operation,and more safety.The last but not the least,the results of arginine stimulation test are consistent with the standard meal test＇s,particularly for the first phase insulin secretion.