钛合金表面抗菌涂层:抗菌能力及生物相容性

Titanium surface covered with antimicrobial coating: antibacterial ability and biocompatibility

背景:钛合金材料因具有良好的生物相容性、耐腐蚀性和综合力学性能被广泛用于临床,如何赋予其优良的抗菌性以应对内植物相关感染是近年来的研究热点。目的:综述了钛合金表面抗菌涂层的原理、技术、分类及优缺点。方法:由第一作者检索1990年1月至2014年1月Scopus数据库、中国科技期刊数据库(重庆维普)相关文献,检索关键词为"Titanium alloy,Plant,Antibacterial,Coating;钛合金,内植物,抗菌,涂层"。结果与结论:根据涂层的种类可将其分为抗生素类涂层、非抗生素类有机抗菌剂涂层、无机抗菌剂类涂层、抗黏附性涂层、抗菌生物活性聚合物涂层,各种涂层均具有较好的生物相容性,但也有各自的局限,目前对抗菌涂层的研究主要集中于:如何增强抗菌涂层与基体的结合力,并获得良好的抗菌性、生物相容性、高耐磨性、持久性是需要研究的关键问题;抗菌相结构、分布对于细菌定植的研究,无论是合金整体添加抗菌元素还是表面涂层型钛合金,抗菌相的结构、分布是影响抗菌性能的关键因素。

BACKGROUND： Titanium alloy with good biocompatibility, corrosion resistance and mechanical properties have been widely used in clinic. How to give its excellent antibacterial properties so as to cope with plant-associated infections has become a research focus in recent years. OBJECTIVE： To review the principle, techniques, classification and relative merits of antimicrobial coating. METHODS： A computer-based search of Scopus database and VIP database was performed by the first author to retrieve relevant articles published from January 1990 to January 2014 using the keywords of ＂titanium alloy, plant, antibacterial, coating＂. RESULTS AND CONCLUSION： Coatings can be classified into antibiotic coating, non-antibiotic organic antimicrobial coating, inorganic antibacterial coating, anti-adhesion coating, antibacterial bioactive polymer coating, all of which have better biocompatibility, but also have their limitations. Current studies concerning antimicrobial coatings mainly focus on how to enhance the binding force between antimicrobial coating and the substrate as well as how to get a good anti-bacterial ability, biocompatibility, high wear resistance and persistence; antibacterial phase structure and distribution effects on the bacterial colonization. The antibacterial phase structure and distribution is the key factor for the antimicrobial properties of titanium alloys with either entirely added anti-bacterial elements or surface coating.