中西药物联合减轻乳腺癌化疗不良反应40例

Combination of Chinese Herbal Medicine and Western Medicine to Reduce the Adverse Reactions of Chemotherapy in Breast Cancer for 40 Cases

目的探讨中西医药物联合法减轻乳腺癌化疗不良反应疗效观察。方法选择我院2010年1月—2014年6月间收治的乳腺癌(已行乳腺癌改良根治术)患者共80例,按照患者的临床治疗方法不同,将所有收录患者分为观察组及对照组,每组各40例患者。对照组患者应用环磷酰胺、氟尿嘧啶及阿霉素常规进行药物化疗,观察组在以上常规药物化疗基础上加用我院自拟中药生血汤进行治疗,对比两组患者的临床治疗效果,进行分析与讨论。结果观察组40例患者中,经中西医药物联合法治疗,其中出现肝肾毒性反应患者5例,出现脱发反应患者18例,出现恶心呕吐反应患者7例,出现白细胞数下降反应患者14例,出现血红蛋白减少反应患者11例,其平均Karnofsky评分约为83.67分左右;相比较对照组40例患者中,其中出现肝肾毒性反应患者13例,出现脱发反应患者24例,出现恶心呕吐反应患者16例,出现白细胞数下降反应患者21例,出现血红蛋白减少反应患者18例,其平均Karnofsky评分约为71.82分左右。即观察组患者应用中西医药物联合法的临床治疗效果显著优于对照组患者应用常规西医药物化疗的临床治疗效果。结论中西医药物联合法可降低乳腺癌化疗患者的临床不良反应,进一步提高患者的生活质量,值得临床进一步研究及探讨。

Objective To explore the effect of combination of traditional Chinese and Western medicine to reduce the adverse reactions of chemotherapy in breast cancer. Methods From January 2010 to June 2014, 80 cases of patiens with breast cancer（underwent modi-fied radical mastectomy）, were selected. According to the different clinical treatment methods, they were divided into observation group and control group, and each group had 40 cases. The control group was treated with cyclophosphamide, 5-fluorouracil and Adriamycin for conventional chemotherapy. The observation group used the self- made Shengxue decoction on the basis of the the conventional chemotherapy. The clinical effect of the two groups were compared, analyzed and discussed. Results 40 patients in the observation group,using the combination of traditional Chinese and Western medicine, 5 cases of patients occurred liver and kidney toxicity, 18 patients had alopecia reaction, 7 cases occurred nausea and vomiting, 14 cases occurred white blood cell count decrease, 11 cases occurred hemoglobin reduction reaction, and the average score of Karnofsky about 83.67. Comparing with the control group of 40 cases, there were 13 cases occurred liver and kidney toxicity, 24 cases of patients had alopecia reaction, 16 cases occurred nausea and vomiting, 21 cases occurred white blood cell count decrease, 18 cases occurred hemoglobin reduction reaction, and the average score of Karnofsky about 71.82. The clinical curative effect of observation group of patients with the combination of traditional Chinese and Western medicine was significantly better than that of the control group which was treated with conventional Western medicine chemotherapy. Conclusion The combination of traditional Chinese and Western medicine can reduce the clinical adverse reaction of breast cancer, further improve the quality of life of patients, and is worthy of further clinical study.