缺血性脑卒中针刺疗效的功能磁共振研究

Study of Acupuncture Therapy on Ischemic Stroke by Function-MRI

目的:应用功能磁共振(function-MRI)技术,观察针刺治疗对缺血性脑卒中患者脑功能区的影响,客观评价针刺对脑梗死患者运动功能疗效。材料和方法:选取健康志愿者30例,急性缺血性脑卒中致偏瘫患者20例,随机分为两组,针刺组与西药组各10例,行NIHSS和BI评分,两组患者西医治疗一致,针刺组于超急性期后行石氏醒脑开窍法治疗。所有志愿者行常规T_2WI、FLAIR扫描,用Block方式双侧手行主动握拳运动模式采集图像,经SPM5后处理软件获得相应脑激活区。随访8周,每周一次,观察fMRI大脑皮层激活位点及强度。数据以±s表示,P<0.05为差异具有显著性。结果:(1)治疗前针刺组与西药组临床评分无统计学差异,治疗后针刺组BI值高于西药组(P<0.05);(2)所有患者均显示随病程发展相应脑皮层激活区面积增大。结论:功能磁共振可用于评价针刺对恢复运动功能的疗效。

Purpose： To investigate the effects of acupuncture on cerebral motor function activities of patients with acute cerebral infarction. Materials and netheds： 30 volunteers and 20 patients （ seperated at randon to acupuncture group and medicine group） with a recent cerebral infarction were chosed. Serial FLAIR and T2 WI scan were performed to all at each week and evaluated with NIHSS and BI during 8 weeks. All volunteers and patients were examined in a block design by hand finger tapping. The dynamic images were postprocessed and analysed by SPM5. The location and quantity of activation in fM- RI were analysed. All data showed with x ±s. Results： （ 1 ） After treatment, the BI was higher in the acupoints group than the medicine group. （2） During the recovery time, the area of activation in all patents was bigger than before. Conclusion： fMRI can provide informations for evaluating acupuncture treatmentat and reflect the motor recovery of the patient .