新辅助同步放化疗治疗局部晚期低位直肠癌的临床效果评价

Neoadjuvant Chemoradiation in the Treatment of Locally Advanced Rectal Cancer Low Effect Assessment

目的探讨分析新辅助同步放化疗治疗局部晚期低位直肠癌的临床效果。方法对2013年1月~2015年1月我院收治的100例局部晚期低位直肠癌患者的临床资料进行回顾性分析,按照随机方法分为对照组与观察组,各50例。对照组患者实施常规手术治疗,观察组患者在术前采取放化疗辅助治疗。观察对比两组患者的不良反应、并发症及治疗效果。结果对照组患者没有接受术前放化疗,因此没有出现不良反应;观察组患者出现1例不良反应,导致手术延迟2天,但是没有人中止放化疗,并且无死亡病例。对照组患者术后并发症发生率为40%,观察组患者术后并发症发生率为14%,对比差异显著,具有统计学意义（P〈0.05）。观察组患者治疗后的肛门括约肌功能优于对照组,对比差异显著,具有统计学意义（P〈0.05）。结论在局部晚期低位直肠癌治疗中,应用新辅助同步放化疗治疗,可减少术后并发症的发生,对提高治疗效果有着积极的意义。

Objective To study the analysis of neoadjuvant chemoradiation clinical effect for the treatment of locally advanced lower rectal cancer. Methods Between January 2013 and January 2015, our hospital 100 cases of locally advanced lower rectal cancer patients were retrospectively analyzed the clinical data, according to the method of random divided into control group and observation group, 50 cases each. Control group, routine surgical treatment for the observation group of patients in preoperative chemoradiotherapy adjuvant therapy. Observe compared two groups of patients with adverse reactions, complications and therapeutic effect. Results The patients with the control group did not receive preoperative chemoradiotherapy, so no adverse reactions; Observation group of patients in 1 cases of adverse reactions, leading to delay 2 days, but no one to suspend the radiation and chemotherapy, and no deaths. Control group patients the incidence of postoperative complications was 40%, the observation group of patients the incidence of postoperative complications was 14%, compared with significant difference, statistically significant（P 0.05）. Observation group of patients after treatment of anal sphincter function was better than control group, significant difference was found in comparison with statistical significance（P〈0.05）. Conclusion In locally advanced rectal cancer treatment, low application neoadjuvant chemoradiation therapy, can significantly reduce the postoperative complications, and is of great significance to improve the treatment effect.