高频振荡通气治疗新生儿呼吸窘迫综合征的临床观察

Clinical Study of High Frequency Oscillatory Ventilation in the Treatment of Newborn Respiratory Distress Syndrome

目的研究高频振荡通气治疗新生儿呼吸窘迫的临床疗效。方法选取符合新生儿呼吸窘迫诊断的患儿40例,随机分为A组HFOV组和B组CMV组,观察治疗前后A组和B组患儿治疗前、治疗48h后的动态血气分析以及氧合指数(OI)及吸入氧分数(Fi O2)变化,并评价患儿合并症以及病情转归的变化。结果治疗后两组患儿Pa O2高于治疗前,治疗后两组患儿Pa CO2、Fi O2和OI低于治疗前,差异显著P=0.00。A组患儿治疗后Pa O2高于B组,A组患儿Pa CO2、Fi O2、OI低于B组;A组并发症低于B组,P=0.00。结论 HFOV治疗新生儿呼吸窘迫综合征,通气效果优于CMV,有效减少并发症的发生,是一种安全、有效的通气模式。

Objective To investigate the clinical efficiency of high frequency oscillatory ventilation in the treatment of newborn respiratory distress syndrome. Methods We enrolled 40 new born baby who was diagnosis as neonatal respiratory distress, and divided into 2 groups randomly, group A was HFOV group, group B was CMV group. Thenobserved dynamic blood gas analysis and oxygenation index（OI） and fractional inspired oxygen（Fi O2） change before and 48 h after treatment in two groups, and evaluation of changes of outcome and complications and disease. Results Pa O2 were significantly higher than those before treatment in both group after the treatment, two groups of patients with Pa CO2, Fi O2 and OI were significantly lower than before treatment, the difference was significantly P=0.00. Pa O2 in group A was significantly higher than group B after treatment,Pa CO2, Fi O2, OI in groups A was significantly lower than group B after treatment, The complication of A group was significantly lower than that of B group, P=0.00. Conclusion HFOV is more efficiency in the treatment of neonatal respiratory distress syndrome then CMV, effectively reduce the incidence of complications, HFOV is a safe, effective ventilation mode.