二甲双胍治疗青春期多囊卵巢综合征的疗效分析及安全性评价

The Clinical Effect and Safety of Metformin to Treat Polycystic Ovarian Syndrome

目的评价二甲双胍治疗青春期多囊卵巢综合征的疗效和安全性。方法 78例患者,分成两组,对照组患者进行优思明治疗,实验组患者进行优思明+二甲双胍治疗。结果实验组患者的多毛、痤疮等临床症状较对照组显著改善,T、LH、FSH、FINS、FPG、BMI指标较对照组显著下降(P<0.05)。结论在优思明治疗的基础上,应用二甲双胍治疗青春期多囊卵巢综合征效果显著,可以改善胰岛素抵抗,减少不良反应。

Objective To evaluate the efficacy and safety of metformin in the treatment of adolescent polycystic ovary syndrome. Methods 78 cases, 39 cases in each. control group were treated with Yasmin treatment, experimental group were Yasmin ＋ dimethyl biguanide treatment. Results The clinical symptoms of patients in the experimental group of hirsutism, acne and other than in the control group improved significantly, t, LH, FSH, fins, FPG, BMI group decreased significantly compared with the control group（P〈0.05）. But the adverse reactions of the two groups of patients had no statistical significance, P〉0.05. Conclusion Based Yasmin treatment, application of metformin in the treatment of adolescent polycystic ovary syndrome has better effects can improve insulin resistance and reduce the adverse reactions.