期刊文献+

动物转基因技术在医学领域的应用

下载PDF
导出
摘要 随着动物转基因技术研究的不断深入和日趋完善,以转基因动物为模型开展人类疾病发病机制、疾病治疗和药物筛选的研究已成为21世纪医学研究的焦点。以转基因动物模型为基础的诱导性多功能干细胞、基因治疗、异种器官移植、疾病动物模型研究在临床医学基础研究中起着重要的作用,它的研究、开发和应用为医学研究提供了保障。
出处 《兽医导刊》 2015年第8期33-35,共3页 Veterinary Orientation
  • 相关文献

参考文献28

  • 1Janeisch R, Mintz B.Simian vires 40 DNA sequences in DNA healthy adult mice derived from preimplantation blastocysts injected with viral DNA[J].Pmc Nat] Acad Sci U S A.1974 ( 04 ) : 1250-4.
  • 2Gordon J W, Scangos G A, Plotkin l) J.Genetic transformation of mouse embryos by microinjection of purified DNA[J].Proc Natl Acad Sci U S A.1980; 77 (12) : 7380-4.
  • 3孙振红,苗向阳,朱瑞良.动物转基因新技术研究进展[J].遗传,2010,32(6):539-547. 被引量:14
  • 4Takahashi K, Yamanaka S.Induction of pluripotent stem cells from meuse embryonic and adult fibroblast euhures by defined factors[J]. Cell, 2006; 126 (04) : 663-76.
  • 5Takahashi K, Tanabe K, Ohnuld M.Induetion of pluripotent stemcells from adult human fibroblasts by defined factors[J].Ce11, 2007 ; 131 (05) : 861-72.
  • 6Yu J, Vodyanik M A, Smuga-Otto K.Induced pluripotent stem cell lines derived from human somatic cells[J].Science, 2007; 318 (5858) : 1917-20.
  • 7Hanna J, Wemig M, Markoulaki S.Treatment of sickle cell anemia mouse model witll iPS ceils generated from autologous skin[J]. Science, 2007; 318 (5858): 1920-3.
  • 8Nakagawa M, Koyanagi M, Tanabe K.Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts[J].NatBiotechnol, 2008; 26 (01): 101-6.
  • 9Park I H, Zhao R, West J A.Reprogramming of human somatic ceils to pluripotency with defined factors[J].Nature, 2008; 451 (7175) : 141-6.
  • 10Dimos J T, Rodolfa K T, Niakan K K, et al.Induced pluripotent stem cells generated from patients with ALS can be differentiated into motor neurons[J].Science, 2008; 321 (5893): 1218-21.

二级参考文献61

  • 1刘兆惠,洛淑萍.基因治疗及其临床应用研究进展[J].生物技术,1996,6(1):1-4. 被引量:5
  • 2卢大儒,邱信芳,薛京伦.基因治疗转移方法研究进展[J].国外医学(遗传学分册),1996,19(1):1-6. 被引量:12
  • 3Janeisch R,Mintz B.Simian virus 40 DNA sequences in DNA healthy adult mice derived from preimplantation blastocysts injected with viral DNA.Proc Natl Acad Sci USA,1974,71(4):1250-1254.
  • 4Brinster RL,Zimmermann JW.Spermatogenesis following male germ-cell transplantation.Proc Natl Acad Sci USA,1994,91(24):11298-11302.
  • 5Nagano M,Brinster CJ,Orwig KE,Ryu BY,Avarbock MR,Brinster RL.Transgenic mice produced by retroviral transduction of male germ-line stem cells.Proc Natl Acad Sci USA,2001,98(23):13090-13095.
  • 6Kanatsu-Shinohara M,Kato M,Takehashi M,Morimoto H,Takashima S,Chuma S,Nakatsuji N,Hirabayashi M,Shinohara T.Production of transgenic rats via lentiviral transduction and xenogeneic transplantation of spermatogonial stem cells.Biol Reprod,2008,79(6):1121-1128.
  • 7Honaramooz A,Megee S,Zeng W,Destrempes MM,Overton SA,Luo J,Galantino-Homer H,Modelski M,Chen F,Blash S,Melican DT,Gavin WG,Avres S,Yang F,Wang PJ,Echelard Y,Dobrinski I.Adeno-associated virus (AAV)-mediated transduction of male germ line stem cells results in transgene transmission after germ cell transplantation.FASEB,2008,22(2):374-382.
  • 8Herpin A,Fischer P,Liedtke D,Kluever N,Neuner C,Raz E,Schartl M.Sequential SDF1a and b-induced mobility guides Medaka PGC migration.Dev Biol,2008,320(2):319-327.
  • 9Naito M,Matsubara Y,Harumi T,Tagami T,Sakurai M,Kuwana T.Foreign gene expression in the gonads of chimaeric chicken embryos by transfer of primordial germ cells transfected in vitro by lipofection for 24 hours.Anim Sci J,2002,71(3):308-311.
  • 10Van de Lavoir MC,Diamond JH,Leighton PA,Mather-Love C,Heyer BS,Bradshaw R,Kerchner A,Hooi LT,Gessaro TM,Swanberg SE,Delany ME,Etches RJ.Germline transmission of genetically modified primordial germ cells.Nature,2006,441(7094):766-769.

共引文献50

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部