抗Hp类药物联合枸橼酸铋钾治疗胃炎的效果

Effect of anti Helicobacter pylori drugs combined with bismuth potassium citrate in the treatment of gastritis

目的分析抗幽门螺杆菌（Hp）类药物联合其他药物治疗胃炎的效果。方法选择本院2011年10月~2013年12月收治的52例胃炎患者,按随机平行对照法分为治疗组与对照组,每组26例。对照组给予抗Hp类药物（阿莫西林、克拉霉素、奥美拉唑）治疗,治疗组在对照组的基础上采用枸橼酸铋钾。两组患者均服药2个疗程,比较其临床治疗效果。结果治疗后,两组的胃痛视觉模拟评分（VAS）和胃泌素水平较治疗前均有改善（P〈0.05）,且治疗组改善情况优于对照组,两组差异有统计学意义（P〈0.05）。治疗组的总有效率为96.15%,显著高于对照组的69.23%,差异有统计学意义（P〈0.05）。两组患者在治疗过程中均未出现不良反应。结论抗HP类药物联合其他药物治疗胃炎具有显著的临床疗效,可以有效抑制并清除Hp,保护胃黏膜,值得临床应用。

Objective To analyze the effects of patients with gastritis using anti Helicobacter pylori （Hp） and combined with other drugs. Methods 52 patients with gastritis in our hospital from October 2011 to December 2013 were selected,they were evenly divided into treatment group and control group according to the random number table method.The control group was given anti-Hp drugs （amoxicillin,clarithromyein and omeprazole）,the treatment group was given additional bismuth potassium citrate on the basis of the control group.Two groups were taking 2 course of treatment,the clinical effects was compared. Results After treatment,stomach pain visual analogue score （VAS） and stomach secrete hormone levels in two groups was improved before treatment （P〈0.05）,and the treatment group was better than the control group,the difference was significant （P〈0.05）.Total effective rate of the treatment group was 96.15%,which was sig- nificantly higher than 69.23% of the control group（P〈0.05）,the difference was significant（P〈0.05）.The two groups during treatment showed no adverse reaction. Conclusion In the treatment of gastritis,anti-Hp drugs combined with other drugs show remarkable clinical efficacy,it can effectively inhibit and remove Hp,protect gastric mucosa.It is worthy of clinical application.