中国楤木粗多糖对糖尿病大鼠的降血糖作用

Hypoglycemic Effect of Crude Polysaccharide Extract from Aralia chinensis on Diabetic Rats

目的:研究中国楤木粗多糖(Aralia chinensis polysaccharide,ACP)对糖尿病大鼠的降血糖作用。方法:采用四氧嘧啶(alloxan,ALX)诱导建立糖尿病大鼠模型,并随机将Sprague-Dawley(SD)大鼠分为正常对照组,糖尿病模型组,ACP高、中、低剂量组,二甲双胍组。连续灌胃给药28 d,测定ACP对糖尿病大鼠空腹血糖(fasting blood glucose,FBG)、糖化血红蛋白(glycosylated hemoglobin A1c,Hb A1c)、总胆固醇(total cholesterol,TC)、甘油三酯(triglyceride,TG)、高密度脂蛋白(high density lipoprotein,HDL)、低密度脂蛋白(low density lipoprotein,LDL)水平的影响。结果:ACP能够有效降低糖尿病大鼠的FBG、Hb A1c、TC、TG水平,提高HDL水平。结论:ACP能够显著降低糖尿病大鼠血糖水平,有效调节糖尿病大鼠血脂代谢紊乱。

Purpose：To observe the hypoglycemic effect of crude polysaccharides from Aralia chinensis roots（APC） on experimental diabetic rats.Methods：A rat model of diabetes was induced through the injection of alloxan.Sprague-Dawley（SD） rats were randomly divided into six groups：low,medium and high ACP dose groups,positive control group,blank control group and diabetic model group.The mice in the treatment groups were administrated with APC for 4 consecutive weeks,and then the changes in fasting blood glucose（FBG）,glycosylated hemoglobin（Hb A1c）,total cholesterol（TC）,triglyceride（TG）,high density lipoprotein（HDL） and low density liporotein（LDL） were determined.Results：ACP could reduce the levels of FBG and Hb A1 c in diabetic rats,decrease the contents of serum TC and TG,significantly increase HDL levels,and result in little change in LDL levels.Conclusion：ACP can effectively ameliorate the metabolism of blood glucose and lipids in diabetic rats.