摘要
microRNAs（miRNAs）是一类内源性的非编码RNA，通过与靶mRNA特异性的结合而导致靶mRNA降解或抑制其翻译，对基因进行转录后调控，进而影响各种生命活动。大量研究表明，miRNAs与辐射致癌效应、辐射增敏效应、肿瘤辐射抗拒和辐射旁效应密切相关，已成为放射医学研究的热点。笔者就miRNAs及其在放射医学研究中的应用作一综述。
MicroRNAs （miRNAs） are endogenous non-coding RNAs, which can degrade their target mRNAs or inhibit their translation by binding to their target mRNAs specifically. MiRNAs act as post-transcriptional regulators of gene expression, and then are involved in diverse physiological activities. Many studies has shown that miRNAs are closely related with radiation carcinogenesis, radiosensitivity, radioresistance and radiation-induced bystander effects, and have being a hotspot in radiation-medicine research. This review focuses on the introduction of miRNAs and their applications in radiation medicine.
出处
《国际放射医学核医学杂志》
2015年第4期332-335,共4页
International Journal of Radiation Medicine and Nuclear Medicine
基金
国家自然科学基金（81172600,81272101）
关键词
微小RNAS
放射医学
辐射致癌
辐射增敏
辐射抗拒
MicroRNAs
Radiation medicine
Radiation carcinogenesis
Radiosensitivity
Radioresistance
