无配体、水相中钯催化的卤代芳烃与苯硼酸的Suzuki偶联反应

Palladium-Catalyzed Suzuki Coupling of Aryl Halides and Arylboronic Acids in Water without Ligand

溴代(碘代)芳烃与苯硼酸在以Li OH为碱、水为反应溶剂、醋酸钯为催化剂、90℃条件下反应24h后,可以较高收率得到二芳基产物。该方法具有收率好,操作方便以及催化体系便宜又简单的优点。

The biaryls can be synthesized through the Suzuki coupling reactions of aryl bromides （or aryl iodide） with arylboronic acids catalyzed by Pd （OAc）2 in the presence of LiOH in water at 90℃ under nitrogen atmosphere for 24 h with good to excellent yields. The method has the advantages of higher yield, more generality, as well as a simpler catalyst system.