沙利度胺对淋巴瘤治疗的研究进展

Advances in thalidomide therapy for lymphoma

淋巴瘤是起源于淋巴结和淋巴组织的免疫系统恶性肿瘤,其发生大多与免疫应答过程中淋巴细胞增殖分化产生的某种免疫细胞恶变有关,以无痛性进行性的淋巴结肿大和局部肿块为特征。按组织病理学改变,淋巴瘤可分为霍奇金淋巴瘤（HL）和非霍奇金淋巴瘤（NHL）。大剂量化疗联合自体干细胞移植是淋巴瘤的主要治疗方式,但仍有部分复发及难治患者不能得到缓解。

The previous studies have shown that thalidomide can change the microenvironment of tumor growth,and plays a role in inhibiting the tumor growth.In recent years,it has been gradually recognized in erythema nodosum leprosum,myeloma and some other diseases.However,more and more clinical studies have demonstrated that it also have some prospects in the treatment of lymphoma.The authors will review the advances in thalidomide therapy for lymphoma.