植物ABCG转运蛋白研究进展

Review of advances in the study of plant ABCG transporters

ABCG转运蛋白是ABC蛋白家族最庞大的亚族,广泛存在于植物体内。ABCG亚族主要由半分子转运蛋白WBC(white-brown complex)和全分子转运蛋白PDR(pleiotropic drug resistance)组成,其底物类型广泛,包括抗生素、植物激素、木质素单体、脂质及次生代谢产物等,涉及植物生命周期中的多种代谢活动。本文综述了植物ABCG转运蛋白的分子特性、结构及功能方面的研究进展,并对今后有关该蛋白的主要研究方向做了展望。

The ATP-binding cassette （ABC）transporters are members of a protein superfamily that constitutes one of the largest protein families known in plants.The ABC subfamily G （ABCG）consists of a single ABC cassette in the amino terminal.ABCG includes both the half-size molecular transporter white-brown complex （WBC）and the full-size molecular transporter pleiotropic drug resistance （PDR）.ABCG is made up of a wide variety of substances （including antibiotics,phytohormones,lignin monolignols,lipids and secondary metabo-lites）that are involved in many kinds of metabolic processes during the plant life cycle.This paper reviews recent advances in studies of the molecular structure and function of ABCG transporters.Research hotspots and future directions are also considered.