嗜铬细胞瘤转移的临床影响因素研究

Prognostic factors for metastasis of pheochromocytomas

收集和分析2002年至2012年上海市瑞金医院内分泌科收治的274例嗜铬细胞瘤患者的临床资料，通过单因素和多因素非转移生存分析探究嗜铬细胞瘤转移的影响因素。结果提示原发肿瘤直径≥6cm和肾上腺外患者非转移生存时间显著降低（P〈0．05）。直径和部位的转移风险比（HR）为1．14和3．38。原发直径和部位是转移的独立影响因素。

Clinical data of 274 cases diagnosed as pheochromocytomas from 2002 to 2012 in Ruijin Hospital were analyzed in this study. Univariate and multivariate analyses of metastasis-free survival were applied. The results suggested that metastatic-free survival of patients with primary tumor 6 cm or more in diameter and extra-adrenal location was significantly lower（ P〈0.05 ）. The hazard ratio for metastasis in larger tumor size and extra-adrenal group was 1.14 and 3.38 respectively. Primary tumor size and location were independent risk factors for metastases.