空腹C肽及餐后2hC肽与空腹C肽比值对初诊2型糖尿病患者血糖波动的影响

Effects of Fasting C-peptide and the Ratio of C_2/C_0 on the Blood Glucose Fluctuation in Newly Diagnosed Type 2 Diabetic Patients

目的探讨空腹C肽(C0)、餐后2 h C肽(C2)与空腹C肽比值(C2/C0)与初诊2型糖尿病患者血糖波动的关系。方法选取2012年4月—2014年3月于泰州市第三人民医院内分泌科住院治疗的初诊2型糖尿病患者54例为研究对象。患者入院后测定C0、食用标准100 g馒头餐后2 h C肽(C2)水平,佩戴动态葡萄糖监测系统进行动态血糖监测72 h,记录日间平均血糖(MBG)、日间平均血糖波动幅度(MAGE)、血糖标准差(SDBG)、最大血糖波动幅度(LAGE)。分别比较C0≥1.1μg/L和<1.1μg/L、C2/C0≥3.0和<3.0患者上述指标水平的差异。结果 C0<1.1μg/L患者MBG、MAGE、SDBG、LAGE高于C0≥1.1μg/L患者,差异有统计学意义(P<0.05)。C2/C0<3.0患者MBG、MAGE、SDBG、LAGE高于C2/C0≥3.0患者,差异有统计学意义(P<0.05)。结论 C0及C2/C0均能影响初诊2型糖尿病患者血糖波动,C0<1.1μg/L和C2/C0<3.0的患者血糖波动较大。

Objective To investigate the effects of fasting C-peptide（C0） and the ratio of C2/C0 on the blood glucose fluctuation in newly diagnosed type 2 diabetic patients.Methods We enrolled 54 newly diagnosed type 2 diabetic patients who were admitted into the Department of Endocrinology of the Third People＇ s Hospital of Taizhou in Jiangsu Province from April 2012 to March 2014.The C0,C2 after 100 g steamed bun intake,72 h dynamic blood glucose monitor by wearing dynamic blood glucose monitoring system,MBG,MAGE,SDBG and LAGE of the patients were tested.The above indicators were compared between the patients with C0≥1.1 μg/L and patients with C0 1.1 μg/L and between patients with C2/C0≥3.0and patients with C2/C0 3.0.Results The patients with C0 1.1 μg/L were significantly higher（P 0.05） than the patients with C0≥1.1 μg/L in MBG,MAGE,SDBG and LAGE.The patients with C2/C0 3.0 were significantly higher（P 0.05） than the patients with C2/C0≥3.0 in MBG,MAGE,SDBG and LAGE.Conclusion Fasting C-peptide and the ratio of C2/C0 both have influence on blood glucose fluctuations in newly diagnosed type 2 diabetic patients.Patients with C0 1.1μg/L and C2/C0 3.0 have greater fluctution in blood glucose.