百草枯中毒患者肺部CT密度变化与预后关系研究

Relationship Between the Changes of Lung CT Density of Patients With Paraquat Poisoning and Prognosis

目的探讨百草枯中毒患者肺部CT密度变化与预后的关系。方法收集2012年5月—2014年4月在广西医科大学第一附属医院确诊为百草枯中毒的患者19例,存活7例（存活组）,死亡12例（死亡组）。选择患者肺部CT不同病变区域横断位图片各2张,肺部CT采用image-pro plus 6.0软件测量各层肺部CT密度,比较存活组、死亡组患者左、右侧病变轻、重层肺部CT密度的大小。结果存活组患者左侧肺部CT密度30.5~83.7,右侧肺部CT密度26.1~79.1;死亡组患者左侧肺部CT密度38.5~184.8,右侧肺部CT密度35.7~183.9。存活组患者左、右侧病变轻层与病变重层肺部CT密度比较,差异无统计学意义（P〉0.05）;死亡组患者左、右侧病变重层肺部CT密度较病变轻层升高（P〈0.05）。存活组与死亡组患者左、右侧病变轻层肺部CT密度比较,差异无统计学意义（P〉0.05）;死亡组患者左、右侧病变重层肺部CT密度较存活组升高（P〈0.05）。结论影像学检查在百草枯中毒导致肺损伤的治疗过程中有重要评估作用,可通过测试肺部CT密度了解病情变化、指导诊疗和评估预后。

Objective To investigate the relationship between the changes of lung CT density of patients with paraquat poisoning and prognosis. Methods 19 patients who were diagnosed with paraquat poisoning in the First Affiliated Hospital of Guangxi Medical University from May 2012 to April 2014. Among them, 7 patients survived （survival group） and 12 patients died （death group） . On both sides of lung, two cross -sectional lung CT images of a high -level lesion area and two cross - sectional lung CT images of a low - level lesion area were selected. Image - pro plus 6.0 was used in lung CT to determine the density of each layer. Comparison was made between survival group and death group in the density of the layer with high - level or low - level lesion on the right side or the left side. Results In the survival group, the lung CT density range was 30. 5 - 83.7 on the left side and 26. 1 -79. 1 on the right side; in the death group, the lung CT density range was 38. 5 - 184. 8 on the left side and 35.7 - 183.9 on the right side. The patients in the survival group were not significantly different （ P 〉 0. 05 ） in lung CT density between the layer with high - level lesion and the layer with low - level lesion on the left side or the right side; the patients in the death group had higher （P 〈 0.05 ） lung CT density in the layer with high - level lesion than in the layer with low - level lesion on the left side or the right side. The survival group and the death group were not significantly different （ P 〉 0. 05 ） in the lung CT density of the layer with low - level lesion on the left side or the right side; the death group had higher （P 〈 0.05 ） lung CT density in the layer with high - level lesion on the left side or the right side than the survival group. Conclusion Imaging examination plays an important role in the treatment of lung injury caused by paraquat poisioning. The test of lung CT density could help monitor the changes of＂ illness condition and provide guidance for the diagnosis, treatment and prognosis.