复方托吡卡胺对中央角膜厚度测量的影响

Effect of compound tropicamide eye drop on measurement of central corneal thickness

目的评价复方托吡卡胺眼液对中央角膜厚度测量的影响及影响持续的时间。方法选择拟行激光角膜屈光手术的近视眼患者120例240眼,分别于点眼前和点眼后1,4 h用OrbscanⅡ眼前节检查系统和非接触反射显微镜SP-2000P测量角膜厚度。结果以OrbscanⅡ测量复方托吡卡胺点眼前、点眼后1 h、点眼后4 h中央角膜厚度(CCT)分别为(545±27),(559±31),(544±26)μm;以SP-2000P测量分别为(508±26),(521±29),(506±24)μm。复方托吡卡胺点眼后1 h与点眼前与相比,2种仪器测量CCT均增加(P<0.01);复方托吡卡胺点眼后4 h与点眼后1 h相比,2种仪器测量CCT均下降(P<0.01);复方托吡卡胺点眼后4 h与点眼前相比,CCT均无变化。结论复方托吡卡胺点眼1 h后使CCT增加;复方托吡卡胺对CCT影响在点眼4 h后消除。准分子激光屈光手术术前检查中,CCT的测量应在复方托吡卡胺点眼前或者点眼后4 h进行。

Objective To evaluate the effect of compound tropicamide eye drops on the measurement of central corneal thickness and to investigate the duration of the effect. Methods In this trial,240 eyes of 120 myopic patients undergoing corneal laser refractive surgery were selected,and central corneal thicknesses were measured before treatment and 1,4h after administration of compound tropicamide eye drops using OrbscanⅡ anterior segment analysis system and SP-2000 P non-contact specular microscope,respectively. Results The central corneal thickness was（ 545 ± 27）,（ 559 ± 31） and（ 544 ± 26） μm before and 1 and4 h after administration,measured with Orbscan Ⅱ anterior segment analysis system, whereas being（ 508 ± 26）,（ 521 ± 29） and（ 506 ± 24） μm measured with SP-2000 P non-contact specular microscope. The central corneal thickness measured with both OrbscanⅡ system and SP-2000 P microscope increased 1 h after administration of compound tropicamide eye drops as compared to that before administration（ P〈0. 01）,and the central corneal thickness measured with both Orbscan Ⅱ system and SP-2000 P microscope decreased 4 h after administration of compound tropicamide eye drops as compared to that 1 h after administration（ P〈0. 01）,while no significant difference was observed in central corneal thickness measured with either Orbscan Ⅱsystem or SP-2000 P microscope between 4 h after administration of Mydrin eye drops and before application.Conclusion Central corneal thickness increases 1 h after the application of compound tropicamide eye drops,and the effect of compound tropicamide eye drops on central corneal thickness is eliminated at 4 h following administration.During the examination prior to excimer laser corneal refractive surgery,measurement of central corneal thickness should be performed before or 4 h after administration of compound tropicamide eye drops.