米诺环素辅助治疗慢性牙周炎临床疗效及安全性评价

Clinical effect and safety for minocycline adjuvant treatment of patients with chronic periodontitis

目的评价米诺环素辅助治疗慢性牙周炎临床疗效及安全性。方法入选62例慢性牙周炎患者,随机分为试验组30例和对照组32例。对照组用刮治、洁治以及根面的平整与修复,试验组在对照组基础上加用米诺环素,每周治疗1次,连续4周。3个月后,比较2组患者菌斑指数(PLI)、牙龈指数(GI)、探诊深度(PD)及附着丧失(AL)。结果 3个月后,试验组与对照组较治疗前菌斑指数、牙龈指数、探诊深度及附着丧失均明显降低(P<0.05),但试验组探诊深度及附着丧失指标显著低于对照组(P<0.05)。试验组出现4例患者一过性疼痛及刺激症状。结论米诺环素辅助治疗慢性牙周炎较单独应用机械治疗临床疗效好。

Objective To evaluate the clinical effect and safety for minocycline treatment of patients with chronic periodontitis. Methods A total of 62 patients with chronic periodontitis were included in this study.All of the patients were treated with mechanic treatment and the patients in the experiment group were also treated with minocycline with 1 time per week for 4 weeks. The plaque index（ PLI）,gingival index（ GI）,probing depth（ PD） and attachment loss（ AL） were evaluated of the two groups after three months treatment. Results After 3 months,the PLI,GI,PD and AL index were significant decreased in both the experiment and control group（ P〈0. 05）. The PD and AL index were significant lower than the control group（ P〈0. 05） after treatment. Four cases of transient pain and irritation symptom were recorded in the experiment group. Conclusion Minocycline combined with mechanic treatment was superior to mechanic treatment alone for patients with chronic periodontitis.