摘要
目的 探讨绝经后女性2型糖尿病(T2DM)合并冠心病的主要相关危险因素。方法 选取2012年1月~2014年6月北京市大兴区红星医院内科住院的绝经后女性2型糖尿病患者335例,其中T2DM非合并冠心病组(无冠心病组)157例,T2DM合并冠心病组(冠心病组)178例。收集两组患者的临床资料;检测空腹血糖(FPG)、糖化血红蛋白(Hb A1c)、三酰甘油(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)及尿酸。结果 冠心病组年龄、糖尿病病程明显高于无冠心病组(P〈0.01);与无冠心病组比较,冠心病组的FPG、Hb A1c、体重指数、收缩压、TC、LDL-C及TG均升高,HDL-C降低(P〈0.05或P〈0.01);冠心病组的患者高血压、肥胖、血脂紊乱、颈动脉斑块及脑卒中发病率均高于无冠心病组,差异均有统计学意义(P〈0.05或P〈0.01);冠心病阳性家族史显著高于无冠心病组(P〈0.01)。Logistic回归分析结果显示,年龄、病程、Hb A1c、LDL-C及收缩压是T2DM合并冠心病的独立危险因素(OR值分别为1.21、1.08、1.49、1.11和1.03,P〈0.05或P〈0.01)。结论 年龄、糖尿病病程、Hb A1c、LDL-C及收缩压与绝经后女性2型糖尿病合并冠心病的发病密切相关。
Objective To investigate the related risk factors of type 2 diabetes mellitus (T2DM) combined with coronary heart disease (CHD) in postmenopausal women. Methods A total of 335 hospitalized postmenopansal women suffering from T2DM without CHD (non-CHD group, 157 cases) and with CHD (CHD group, 178 cases) were enrolled from Jan- uary 2012 to June 2014. Clinical data were collected and the levels of fasting plasma glucose (FPG), glycated hemoglobin (HbAlo), triglycerides (TG), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C) and blood uric acid (UA) were detected. Results Compared with the non-CHD group,the CHD group showed significantly greater age and longer duration of diabetes (P 〈 0.01). Further, the CHD group had higher levels of fasting blood glucose, glycosylated hemoglobin, BMI, systolic blood pressure, TC, LDL-C and TG, and lower level of HDL-C (P 〈 0.05 or P 〈 0.01). The incidences of hypertension, obesity, dyslipidemia, carotid artery plaque, cerebral stroke of CHD group were all higher than those of non-CHD group, the differences were statistically signifi- cant (P 〈 0.05 or P 〈 0.01). Logistic analysis showed that, age, duration of diabetes mellitus, HbAlc, LDL-C, and sys- tolic blood pressure were the independent risk factors of T2DM combined with coronary heart disease (OR=1.21, 1.11, 1.49, 1.08 and 1.03; P 〈 0.05 or P 〈 0.01). Conclusion Age, duration of diabetes mellitus, HbAlc, LDL-C, and systolic blood pressure are closely related to the incidence of type 2 diabetes mellitus combined with coronary heart disease in postmenopausal women.
出处
《中国医药导报》
CAS
2015年第21期35-38,共4页
China Medical Herald
关键词
绝经后女性
2型糖尿病
冠心病
危险因素
Postmenopausal women
Type 2 Diabetes meUitus
Coronary heart disease
Risk factor