益生菌联合三联疗法治疗幽门螺杆菌相关性慢性胃炎的临床效果

Clinical effect of probiotics combined with triple therapy in the treatment of Helicobacter pylori associated chronic gastritis

目的 观察益生菌联合三联疗法治疗幽门螺杆菌相关性慢性胃炎的临床效果及预后。方法 选择深圳市石岩人民医院2013年3月~2014年1月收治的幽门螺杆菌相关性慢性胃炎患者110例作为研究对象,并将其按奇偶数随机分为对照组（50例）和治疗组（60例）。对照组给予单纯三联疗法（奥美拉唑40 mg,2次/d＋克拉霉素0.5 g,2次/d＋阿莫西林1.0 g,2次/d）治疗;治疗组在此基础上加用益生菌（双歧杆菌乳杆菌三联活菌片,1片/次,3次/d）。观察比较两组治疗4周后临床效果及不良反应发生情况,随访1年后,观察复发率。结果 对照组痊愈13例,显效18例,有效11例,总有效率为84.0%;治疗组痊愈22例,显效25例,有效11例,总有效率为96.7%,治疗组总有效率显著高于对照组,差异有统计学意义（P〈0.05）;随访1年后,治疗组复发率（6.7%）显著低于对照组（22.0%）,差异有统计学意义（P〈0.05）。对照组有6例（12.0%）出现不良反应,其中恶心2例,呕吐1例,头晕3例;治疗组有2例（3.3%）出现不良反应,其中恶心1例,头晕1例,两组不良反应发生率比较差异无统计学意义（χ^2=1.89,P〉0.05）。结论 益生菌联合三联疗法治疗幽门螺杆菌相关性慢性胃炎效果良好,并可有效降低复发率。

Objective To observe the clinical curative effect and prognosis of probiotics combined with triple therapy for Helicobacter pylori associated chronic gastritis. Methods One hundred and ten cases of patients with Helicobacter pylori associated chronic gastritis admitted to Shiyan People＇s Hospital of Shenzhen City from March 2013 to January 2014 were randomly divided into control group （50 cases） and treatment group （60 cases） according to odd-even num- ber. The control group was only given single triple therapy （Omeprazole 40 rag, twice a day ＋ Clarithromycin 0.5 g, twice a day ＋ Amoxieillin 1.0 g, twice a day）; while on basis of control group, the treatment group was added with pro- biotics （Live Combined Bifidobacterium and Lactobacillus Tablets, once 1 tablet, 3 times a day）. The clinical effect and adverse reactions after treatment for 4 weeks of the two groups were observed and compared, after follow-up for one year, the recurrence rate was observed. Results In the control group, there were 13 cases of cure, 18 cases of excellent, 11 cases of valid, the total effective rate was 84.0%; in the treatment group, there were 22 cases of cure, 25 cases of excellent, 11 cases of valid, the total effective rate was 96.7%. The total effective rate of treatment group was higher than that of control group, the difference was statistically significant （P 〈 0.05）. After follow-up for one year, the recur- rence rate （6.7%） of treatment group was lower than that of control group （22.0%）, the difference was statistically signif- icant （P 〈 0.05）. There were 6 cases of adverse reactions in the control group, among which, there were 2 cases of nau- sea, 1 case of emesis, 3 cases of dizziness; there were 2 cases of adverse reactions in the treatment group, among which, there was 1 case of nausea, 1 case of dizziness, there was no statistically significant difference of adverse reactions between the two groups （x^2=1.89, P 〉 0.05）. Conclusion Probioties combined with triple therapy in the treatment of Helicobacter pylori associated chronic gastritis has a good effect, and it can effectively reduce the recurrence rate.