Prostasin基因多态性与早发型重度子痫前期妊娠结局的相关性

Association of prostasin gene rs12597511 polymorphism with outcomes of pregnancy with severe preeclampsia

目的探讨prostasin基因多态性与早发型重度子痫前期妊娠结局的相关性。方法收集2011年3月至2012年4月于本院就诊的401位孕妇的妊娠结局及基因型等信息，其中正常足月妊娠222位为对照组；重度子痫前期患者按发病时间分为早发组（79例）和晚发组（100例）。结果早发组TC／CC基因型者总并发症及肝脏损害发生率、围产儿死亡率、新生儿窒息和颅内出血发生率均高于1vr基因型（P〉0．05）。Logistic回归分析显示TC／CC基因型、24h尿蛋白和发病孕周是重度子痫前期并发症的风险因素（OR=1．049，95％CI=1．0071．093，P=0．021；OR=1．031，95％CI=0．350~0．883，P=0．013；OR=0．733，95％CI=0．566～0．950，P=0．019），围产儿死亡则与终止妊娠孕周有关（OR=0．542，95％CI=0．331—0．887，P=0．015）。结论Prostasin基因多态性与早发型重度子痫前期不良妊娠结局存在相关性。

Objective To assess the association of prostasin gene rs12597511 polymorphism with clinical features and pregnancy outcomes among patients with severe preeclampsia. Methods Clinical manifestations, pregnancy outcomes and the genotypes of 179 patients with severe preeclampsia [＇early-onset group （≤ 34 gestational weeks） ： 79 cases; Late-onset group （〉 34 gestational weeks） ： 100 cases] and 222 normal-term pregnant women （control group） were collected. Results In the early-onset group, the patients with TC or CC genotype at rs12597511 had higher incidences of total complications, liver dysfunction, neonatal asphyxia, neonatal intracranial hemorrhage and perinatal mortality compared with those with TT genotype （P〉0.05）. Multiple logistic regression analysis showed that the complication rates of severe preeclampsia patients are closely related to TC or CC genotypes, 24 h urinary protein and gestational weeks of onset （OR= 1. 049, 95%CI=1. 007-1. 093, P：0. 021; OR=1. 031, 95%CI=0. 350- 0. 883,P=0. 013; OR=0. 733, 95%CI=0. 566-0. 950, P：0. 019）, and the perinatal mortality is related to gestational weeks at delivery （OR：O. 542,95%CI=0. 331-0. 887, P：0. 015）. Conclusion Polymorphism of the prostasin gene is closely associated with poor pregnancy outcomes of early-onset severe preeclampsia.