雷公藤多甙联合丹参注射液治疗变应性血管炎及对血清β2-MG影响

Tripterygium Glycosides Wilfordii Combined with Salvia Miltiorrhiza Injection on Treating Allergic Vasculitis and Its Effect on Serum β2-MG Level

目的评价雷公藤多甙联合丹参注射液治疗变应性血管炎的疗效及血清β2-MG水平的变化。方法对治疗组73例变应性血管炎患者,予以雷公藤多甙口服,同时静脉滴注丹参注射液;对照组69例,予以西替利嗪、吲哚美辛口服。2组同时应用维生素C及钙剂,对有感染症状的病例适当给予抗生素治疗。对比2组治疗前后皮损改善及外周血清β2-MG水平的变化。结果在疗程结束后,治疗组总有效率为78.08%,与对照组相比,差异有统计学意义。与本组治疗前及对照组治疗后相比,血清β2-MG下降程度差异有统计学意义。结论雷公藤多甙起活血通络与抗炎作用,丹参起活血化瘀、改善微循环作用。两者联合应用,能很好改善变应性血管炎患者的皮肤及肾脏病变,临床效果满意。

Objective To evaluate the effects of tripterygium glycosides wilfordii combined with salvia miltiorrhiza injection on the treatment of allergic vasculitis and its effect on serum β2-MG level. Methods 73 cases of allergic vasculitis in the treatment group were treated with taking tripterygium and intravenous dripping salvia miltiorrhiza injection. 69 cases in the control group were treated with taking cetirizine and indomethacin. The patients in two groups were taken vitamin C and calcium also. Any patient with symptoms of infection took antibiotics at the same time. The improvements of skin symptoms and the changes of serum β2-MG level in the two groups before and after the treatment were compared. Results After the treatment,effective rate of treatment group was 78.08% and higher than that in the controls. There was a statistically significant between two groups. The level of serum β2-MG of the treatment group was significant less than that before. After treatment, the decreasing of serum β2-MG was statistically significant between treatment group and control group. Conclusion Tripterygium can improve the circulation and collateral channels, also play role of anti-inflammation. Salvia miltiorrhiza promote blood circulation and removing blood stasis. Combination of the two therapy can effectively improve the skin and renal lesions of patients with allergic vasculitis. The clinical effect is satisfactory.